Photodynamic therapy for radiation maculopathy: A case report.


Journal

Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R

Informations de publication

Date de publication:
09 Apr 2021
Historique:
received: 25 11 2020
accepted: 04 02 2021
entrez: 9 4 2021
pubmed: 10 4 2021
medline: 16 4 2021
Statut: ppublish

Résumé

The best treatment protocol for radiation maculopathy in children has not been determined. The purpose of this study was to determine the effect of photodynamic therapy (PDT) on radiation maculopathy. An 11-year-old boy who was originally diagnosed with orbital rhabdomyosarcoma when he was 1 year old, in October 2008. The lesion improved after peripheral blood stem cell transplantation, chemotherapy and radiation therapy. A cataract was detected in his right eye in May 2011, and he underwent cataract surgery in July 2011. Continuous amblyopia training maintained his visual acuity in his right eye. In January 2017, his visual acuity was reduced and macular edema was detected with optical coherence tomography. We diagnosed radiation maculopathy, from the history of radiation therapy, macular edema by optical coherence tomography, and hyperfluorescent site by fluorescein angiography. We performed PDT in June 2017. Treatment with PDT improved macular edema and his visual acuity. Radiation retinopathy is progressive disorder with poor prognosis. PDT could be considered to treat radiation maculopathy.

Identifiants

pubmed: 33832069
doi: 10.1097/MD.0000000000024888
pii: 00005792-202104090-00013
pmc: PMC8036116
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e24888

Informations de copyright

Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

Déclaration de conflit d'intérêts

The authors have no conflicts of interest to disclose.

Références

Gass JDM. Stereoscopic atlas of macular diseases, diagnosis and treatment. 3rd ed.1987;St.Louis: Mosby, 404-5.
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Kinyoun JL, Chittum ME, Wells CG. Photocoagulation treatment of radiation retinopathy. Am J Ophthalmol 1988;105:470–8.
Singh AD, Pabon S, Aronow ME. Management of radiation maculopathy. Ophthalmic Res 2012;48: (Suppl 1): 26–31. doi: 10.1159/000339844.
doi: 10.1159/000339844
Bakri SJ, Beer PM. Photodynamic therapy for maculopathy due to radiation retinopathy. Eye 2005;19:795–9.
Parsons JT, Bova FJ, Fitzgerald CR, et al. Radiation retinopathy after external-beam irradiation: analysis of time-dose factors. Int J Radiat Oncol Biol Phys 1994;30:765–73.
Brown GC, Shields JA, Sanborn G, et al. Radiation retinopathy. Ophthalmology 1982;89:1494–501.
Schlotzer-Schrehardt U, Viestenz A, Naumann GO, et al. Dose-related structural effects of photodynamic therapy on choroidal and retinal structures of human eyes. Graefes Arch Clin Exp Ophthalmol 2002;240:748–57.

Auteurs

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