Profiles of 5α-Reduced Androgens in Humans and Eels: 5α-Dihydrotestosterone and 11-Ketodihydrotestosterone Are Active Androgens Produced in Eel Gonads.
11KDHT
5α-reductase
DHT
androgen receptor
testosterone
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
01
2021
accepted:
26
02
2021
entrez:
9
4
2021
pubmed:
10
4
2021
medline:
24
12
2021
Statut:
epublish
Résumé
Although 11-ketotestosterone (11KT) and testosterone (T) are major androgens in both teleosts and humans, their 5α-reduced derivatives produced by steroid 5α-reductase (SRD5A/srd5a), i.e., 11-ketodihydrotestosterone (11KDHT) and 5α-dihydrotestosterone (DHT), remains poorly characterized, especially in teleosts. In this study, we compared the presence and production of DHT and 11KDHT in Japanese eels and humans. Plasma 11KT concentrations were similar in both male and female eels, whereas T levels were much higher in females. In accordance with the levels of their precursors, 11KDHT levels did not show sexual dimorphism, whereas DHT levels were much higher in females. It is noteworthy that plasma DHT levels in female eels were higher than those in men. In addition, plasma 11KDHT was undetectable in both sexes in humans, despite the presence of 11KT. Three srd5a genes (
Identifiants
pubmed: 33833737
doi: 10.3389/fendo.2021.657360
pmc: PMC8021924
doi:
Substances chimiques
11-ketodihydrotestosterone
0
Androgens
0
Membrane Proteins
0
Receptors, Androgen
0
Dihydrotestosterone
08J2K08A3Y
Testosterone
3XMK78S47O
3-Oxo-5-alpha-Steroid 4-Dehydrogenase
EC 1.3.99.5
SRD5A1 protein, human
EC 1.3.99.5
SRD5A2 protein, human
EC 1.3.99.5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
657360Informations de copyright
Copyright © 2021 Yazawa, Inaba, Imamichi, Sekiguchi, Uwada, Islam, Orisaka, Mikami, Ida, Sato, Miyashiro, Takahashi, Khan, Suzuki, Umezawa and Kitano.
Déclaration de conflit d'intérêts
Author YM was employed by the company ASKA Pharmaceutical Medical Co., Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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