Dental Pulp Stem Cells on Implant Surface: An In Vitro Study.
Bone Matrix
/ drug effects
Cell Adhesion
/ drug effects
Cell Death
/ drug effects
Cell Proliferation
/ drug effects
Culture Media, Conditioned
/ pharmacology
Dental Implants
Dental Pulp
/ cytology
Humans
Neovascularization, Physiologic
/ drug effects
Osseointegration
/ drug effects
Osteocalcin
/ metabolism
Stem Cells
/ cytology
Surface Properties
Vascular Endothelial Growth Factor A
/ metabolism
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
12
08
2020
revised:
28
10
2020
accepted:
14
03
2021
entrez:
9
4
2021
pubmed:
10
4
2021
medline:
26
5
2021
Statut:
epublish
Résumé
In the field of biology and medicine, one hears often about stem cells and their potential. The dental implant new surfaces, subjected to specific treatments, perform better and allow for quicker healing times and better clinical performance. The purpose of this study is to evaluate from a biological point of view the interaction and cytotoxicity between stem cells derived from dental pulp (DPSCs) and titanium surfaces. Through the creation of complex cells/implant, this study is aimed at analyzing the cytotoxicity of dental implant surfaces (Myth (Maipek Manufacturer Industrial Care, Naples, Italy)) and the adhesion capacity of cells on them and at considering the essential factors for implant healing such as osteoinduction and vasculogenesis. These parameters are pointed out through histology (3D cell culture), immunofluorescence, proliferation assays, scanning electron microscopy, and PCR investigations. The results of the dental implant surface and its interaction with the DPSCs are encouraging, obtaining results increasing the mineralization of the tissues. The knowledge of this type of interaction, highlighting its chemical and biological features, is certainly also an excellent starting point for the development of even more performing surfaces for having better healing in the oral surgical procedures related to dental implant positioning.
Identifiants
pubmed: 33834063
doi: 10.1155/2021/3582342
pmc: PMC8012148
doi:
Substances chimiques
Culture Media, Conditioned
0
Dental Implants
0
Vascular Endothelial Growth Factor A
0
Osteocalcin
104982-03-8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3582342Informations de copyright
Copyright © 2021 Luigi Laino et al.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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