Effects of an urban sanitation intervention on childhood enteric infection and diarrhea in Maputo, Mozambique: A controlled before-and-after trial.
Bacterial Infections
/ diagnosis
Child, Preschool
Diarrhea
/ epidemiology
Dysentery, Bacillary
/ epidemiology
Female
Helminthiasis
/ diagnosis
Humans
Infant
Male
Mozambique
/ epidemiology
Prevalence
Reinfection
Residence Characteristics
Sanitary Engineering
Soil
/ parasitology
Time Factors
Toilet Facilities
Trichuriasis
/ epidemiology
Urban Health
diarrhea
enteric infection
environmental health
epidemiology
global health
human
medicine
neglected tropical diseases
sanitation
soil-transmitted helminths
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
09 04 2021
09 04 2021
Historique:
received:
20
08
2020
accepted:
03
04
2021
pubmed:
10
4
2021
medline:
27
10
2021
entrez:
9
4
2021
Statut:
epublish
Résumé
We conducted a controlled before-and-after trial to evaluate the impact of an onsite urban sanitation intervention on the prevalence of enteric infection, soil transmitted helminth re-infection, and diarrhea among children in Maputo, Mozambique. A non-governmental organization replaced existing poor-quality latrines with pour-flush toilets with septic tanks serving household clusters. We enrolled children aged 1-48 months at baseline and measured outcomes before and 12 and 24 months after the intervention, with concurrent measurement among children in a comparable control arm. Despite nearly exclusive use, we found no evidence that intervention affected the prevalence of any measured outcome after 12 or 24 months of exposure. Among children born into study sites after intervention, we observed a reduced prevalence of
Identifiants
pubmed: 33835026
doi: 10.7554/eLife.62278
pii: 62278
pmc: PMC8121544
doi:
pii:
Substances chimiques
Soil
0
Banques de données
ClinicalTrials.gov
['NCT02362932']
Types de publication
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Knee et al.
Déclaration de conflit d'intérêts
JK, TS, ZA, CA, FB, DC, VC, DH, PK, EM, JB, CR, WS, JS, WZ, RN, OC, JB As we have indicated on the ICMJE COI form, attached, this authors's time working on this study was funded in part by the study's funders, the United States Agency for International Development and the Bill and Melinda Gates Foundation. AM, VZ No competing interests declared
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