Airborne Benzo[a]Pyrene may contribute to divergent Pheno-Endotypes in children.
8-Hydroxy-2'-Deoxyguanosine
/ urine
Adolescent
Air Pollutants
/ analysis
Asthma
/ blood
Benzo(a)pyrene
/ analysis
Case-Control Studies
Child
Child, Preschool
Cotinine
/ urine
Czech Republic
/ epidemiology
Dinoprost
/ analogs & derivatives
Environmental Exposure
/ analysis
Female
Humans
Infant
Lung
/ physiopathology
Male
Phenotype
8-oxo-7,8-dihydro-2′-deoxyguanosine
Air pollution
Benzo[a]pyrene
Endotype;15-Ft2-isoprostane
Journal
Environmental health : a global access science source
ISSN: 1476-069X
Titre abrégé: Environ Health
Pays: England
ID NLM: 101147645
Informations de publication
Date de publication:
09 04 2021
09 04 2021
Historique:
received:
08
07
2020
accepted:
01
03
2021
entrez:
10
4
2021
pubmed:
11
4
2021
medline:
31
8
2021
Statut:
epublish
Résumé
Asthma represents a syndrome for which our understanding of the molecular processes underlying discrete sub-diseases (i.e., endotypes), beyond atopic asthma, is limited. The public health needs to characterize etiology-associated endotype risks is becoming urgent. In particular, the roles of polyaromatic hydrocarbon (PAH), globally distributed combustion by-products, toward the two known endotypes - T helper 2 cell high (Th2) or T helper 2 cell low (non-Th2) - warrants clarification. To explain ambient B[a]P association with non-atopic asthma (i.e., a proxy of non-Th2 endotype) is markedly different from that with atopic asthma (i.e., a proxy for Th2-high endotype). In a case-control study, we compare the non-atopic as well as atopic asthmatic boys and girls against their respective controls in terms of the ambient Benzo[a]pyrene concentration nearest to their home, plasma 15-F The non-atopic asthma cases are associated with a significantly higher median B[a]P (11.16 ng/m Ambient B[a]P is robustly associated with non-atopic asthma, while it has no clear associations with atopic asthma among lean children. Furthermore, lung function deficit, 15-F
Sections du résumé
BACKGROUND
Asthma represents a syndrome for which our understanding of the molecular processes underlying discrete sub-diseases (i.e., endotypes), beyond atopic asthma, is limited. The public health needs to characterize etiology-associated endotype risks is becoming urgent. In particular, the roles of polyaromatic hydrocarbon (PAH), globally distributed combustion by-products, toward the two known endotypes - T helper 2 cell high (Th2) or T helper 2 cell low (non-Th2) - warrants clarification.
OBJECTIVES
To explain ambient B[a]P association with non-atopic asthma (i.e., a proxy of non-Th2 endotype) is markedly different from that with atopic asthma (i.e., a proxy for Th2-high endotype).
METHODS
In a case-control study, we compare the non-atopic as well as atopic asthmatic boys and girls against their respective controls in terms of the ambient Benzo[a]pyrene concentration nearest to their home, plasma 15-F
RESULTS
The non-atopic asthma cases are associated with a significantly higher median B[a]P (11.16 ng/m
CONCLUSIONS
Ambient B[a]P is robustly associated with non-atopic asthma, while it has no clear associations with atopic asthma among lean children. Furthermore, lung function deficit, 15-F
Identifiants
pubmed: 33836759
doi: 10.1186/s12940-021-00711-4
pii: 10.1186/s12940-021-00711-4
pmc: PMC8035778
doi:
Substances chimiques
Air Pollutants
0
8-epi-prostaglandin F2alpha
27415-26-5
Benzo(a)pyrene
3417WMA06D
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
Dinoprost
B7IN85G1HY
Cotinine
K5161X06LL
Banques de données
figshare
['10.6084/m9.figshare.14396838.v1']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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