Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.
Adenosine
/ metabolism
Animals
Brain
/ pathology
Caffeine
/ pharmacology
Cell Line, Tumor
Chronobiology Disorders
/ drug therapy
Circadian Clocks
/ drug effects
Circadian Rhythm
/ drug effects
Disease Models, Animal
Humans
Light
Male
Mice
Mice, Transgenic
Period Circadian Proteins
/ genetics
Photoperiod
Quinazolines
/ administration & dosage
Receptor, Adenosine A1
/ metabolism
Receptor, Adenosine A2A
/ metabolism
Signal Transduction
/ drug effects
Sleep
/ drug effects
Sleep Deprivation
/ complications
Triazoles
/ administration & dosage
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 04 2021
09 04 2021
Historique:
received:
31
08
2019
accepted:
18
02
2021
entrez:
10
4
2021
pubmed:
11
4
2021
medline:
4
5
2021
Statut:
epublish
Résumé
The accumulation of adenosine is strongly correlated with the need for sleep and the detection of sleep pressure is antagonised by caffeine. Caffeine also affects the circadian timing system directly and independently of sleep physiology, but how caffeine mediates these effects upon the circadian clock is unclear. Here we identify an adenosine-based regulatory mechanism that allows sleep and circadian processes to interact for the optimisation of sleep/wake timing in mice. Adenosine encodes sleep history and this signal modulates circadian entrainment by light. Pharmacological and genetic approaches demonstrate that adenosine acts upon the circadian clockwork via adenosine A
Identifiants
pubmed: 33837202
doi: 10.1038/s41467-021-22179-z
pii: 10.1038/s41467-021-22179-z
pmc: PMC8035342
doi:
Substances chimiques
Adora2a protein, mouse
0
Per1 protein, mouse
0
Per2 protein, mouse
0
Period Circadian Proteins
0
Quinazolines
0
Receptor, Adenosine A1
0
Receptor, Adenosine A2A
0
Triazoles
0
Caffeine
3G6A5W338E
Adenosine
K72T3FS567
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine
Y5A5D5E2AQ
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2113Subventions
Organisme : NINDS NIH HHS
ID : R01 NS103740
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS065957
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N001664/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT106174/Z/14/ZMA
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14103
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/N01992X/1
Pays : United Kingdom
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