Fornix white matter microstructure differentially predicts false recollection rates in older and younger adults.
Diffusion weighted imaging
False memory
Older adults
Journal
Neuropsychologia
ISSN: 1873-3514
Titre abrégé: Neuropsychologia
Pays: England
ID NLM: 0020713
Informations de publication
Date de publication:
16 07 2021
16 07 2021
Historique:
received:
09
03
2020
revised:
26
03
2021
accepted:
28
03
2021
pubmed:
11
4
2021
medline:
29
6
2021
entrez:
10
4
2021
Statut:
ppublish
Résumé
Healthy aging is accompanied by increased false remembering in addition to reduced successful remembering in older adults. Neuroimaging studies implicate age-related differences in the involvement of medial temporal lobe and fronto-parietal regions in mediating highly confident false recollection. However, no studies have directly examined the relationship between white matter microstructure and false recollection in younger and older adults. Using diffusion-weighted imaging and probabilistic tractography, we examined how white matter microstructure within tracts connecting the hippocampus and the fronto-parietal retrieval network contribute to false recollection rates in healthy younger and older adults. We found only white matter microstructure within the fornix contributed to false recollection rates, and this relationship was specific to older adults. Fornix white matter microstructure did not contribute to true recollection rate, nor did common white matter contribute to false recollection, suggesting fornix microstructure is explicitly associated with highly confident false memories in our sample of older adults. These findings underlie the importance of examining microstructural correlates associated with false recollection in younger and older adults.
Identifiants
pubmed: 33838146
pii: S0028-3932(21)00099-3
doi: 10.1016/j.neuropsychologia.2021.107848
pmc: PMC8674925
mid: NIHMS1693736
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
107848Subventions
Organisme : NIA NIH HHS
ID : K99 AG056670
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG056670
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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