The therapeutic potentials of apelin in obesity-associated diseases.
Animals
Anti-Obesity Agents
/ therapeutic use
Apelin
/ genetics
Apelin Receptors
/ genetics
Diabetes Mellitus, Type 2
/ drug therapy
Diabetic Cardiomyopathies
/ drug therapy
Dipeptidyl-Peptidase IV Inhibitors
/ therapeutic use
Energy Metabolism
/ drug effects
Gene Expression Regulation
Homeostasis
/ drug effects
Humans
Hypoglycemic Agents
/ therapeutic use
Metformin
/ therapeutic use
Obesity
/ drug therapy
Signal Transduction
APJ
Apelin
Cardiomyopathy
Energy metabolism
Obesity
Type 2 diabetes
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
received:
01
02
2021
revised:
26
03
2021
accepted:
02
04
2021
pubmed:
11
4
2021
medline:
15
12
2021
entrez:
10
4
2021
Statut:
ppublish
Résumé
Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has emerged as an adipokine more than fifteen years ago, integrating the field of inter-organs interactions. The apelin/APJ system plays important roles in several physiological functions both in rodent and humans such as fluid homeostasis, cardiovascular physiology, angiogenesis, energy metabolism. Thus the apelin/APJ system has generated great interest as a potential therapeutic target in different pathologies. The present review will consider the effects of apelin in metabolic diseases such as obesity and diabetes with a focus on diabetic cardiomyopathy among the complications associated with diabetes and APJ agonists or antagonists of interest in these diseases.
Identifiants
pubmed: 33838166
pii: S0303-7207(21)00122-2
doi: 10.1016/j.mce.2021.111278
pii:
doi:
Substances chimiques
APLN protein, human
0
APLNR protein, human
0
Anti-Obesity Agents
0
Apelin
0
Apelin Receptors
0
Dipeptidyl-Peptidase IV Inhibitors
0
Hypoglycemic Agents
0
Metformin
9100L32L2N
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111278Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.