Serum hs-CRP measured prior transplantation predicts of new-onset diabetes after transplantation in renal transplant recipients.
Hs-CRP
NODAT prediction
Renal transplant recipients
Journal
Transplant immunology
ISSN: 1878-5492
Titre abrégé: Transpl Immunol
Pays: Netherlands
ID NLM: 9309923
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
03
12
2020
revised:
29
03
2021
accepted:
04
04
2021
pubmed:
11
4
2021
medline:
25
12
2021
entrez:
10
4
2021
Statut:
ppublish
Résumé
To assess the incidence of new-onset diabetes after transplantation (NODAT) for the first year post-transplantation and the predictive value of high-sensitivity C-reactive Protein (hs-CRP) before transplantation for NODAT prediction in kidney transplantation patients. A study of 251 consecutive adult end-stage kidney disease patients transplanted kidneys from living donors, follow-up during the first year to find NODAT. We diagnosed NODAT based on blood glucose or HbA1c following to the criteria of the American Diabetes Association. The ratio of NODAT was 12.4%. The mean age, mean BMI, the proportion of arteriosclerosis, and the median hs-CRP level in NODAT group were significantly higher than those of non-NODAT group with p < 0.05. Age, BMI and serum hs-CRP had a predictive value for NODAT (Age: AUC = 0.62, p < 0.05, BMI: AUC = 0.626, hs-CRP: AUC = 0.748, p < 0.001). Serum hs-CRP level measured prior transplantation is a good predictor for NODAT in renal transplant recipients.
Sections du résumé
BACKGROUND
To assess the incidence of new-onset diabetes after transplantation (NODAT) for the first year post-transplantation and the predictive value of high-sensitivity C-reactive Protein (hs-CRP) before transplantation for NODAT prediction in kidney transplantation patients.
MATERIAL AND METHODS
A study of 251 consecutive adult end-stage kidney disease patients transplanted kidneys from living donors, follow-up during the first year to find NODAT. We diagnosed NODAT based on blood glucose or HbA1c following to the criteria of the American Diabetes Association.
RESULTS
The ratio of NODAT was 12.4%. The mean age, mean BMI, the proportion of arteriosclerosis, and the median hs-CRP level in NODAT group were significantly higher than those of non-NODAT group with p < 0.05. Age, BMI and serum hs-CRP had a predictive value for NODAT (Age: AUC = 0.62, p < 0.05, BMI: AUC = 0.626, hs-CRP: AUC = 0.748, p < 0.001).
CONCLUSION
Serum hs-CRP level measured prior transplantation is a good predictor for NODAT in renal transplant recipients.
Identifiants
pubmed: 33838297
pii: S0966-3274(21)00032-0
doi: 10.1016/j.trim.2021.101392
pii:
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101392Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.