Patch testing with sodium disulfite: North American Contact Dermatitis Group experience, 2017 to 2018.
Adult
Aged
Beverages
/ adverse effects
Cosmetics
/ adverse effects
Cross-Sectional Studies
Dermatitis, Allergic Contact
/ diagnosis
Female
Food
/ adverse effects
Humans
Male
Middle Aged
Occupational Exposure
/ adverse effects
Patch Tests
/ methods
Retrospective Studies
Sulfites
/ administration & dosage
Young Adult
CAS 7681-57-4
allergic contact dermatitis
contact allergy
patch tests
sodium disulfite
sodium metabisulfite
sulfites
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
23
03
2021
received:
21
02
2021
accepted:
07
04
2021
pubmed:
13
4
2021
medline:
17
12
2021
entrez:
12
4
2021
Statut:
ppublish
Résumé
Sodium disulfite (SD), also known as sodium metabisulfite, is an increasingly recognized cause of allergic contact dermatitis. The objective of this work was to characterize individuals with positive patch test reactions to SD as well as analyse reaction strength, clinical relevance, and sources. This is a retrospective analysis of patients patch tested with SD (1% petrolatum) by the North American Contact Dermatitis Group (NACDG), 2017 to 2018. Of 4885 patients patch tested with SD, 132 (2.7%) had a positive reaction. Common primary anatomic sites of dermatitis were face (28.8%), hands (20.5%), and a scattered/generalized distribution (13.6%). Compared with SD-negative patients, SD-positive patients were more likely male (odds ratio 2.81, 95% confidence interval 1.98-4.00) and/or over 40 years (odds ratio 1.95, 95% confidence interval 1.30-2.94). Reactions were most commonly + (50.4%) or ++ (34.1%); 65.2% were considered currently relevant. About 15.2% were definitively confirmed in sources, commonly personal care products (18.9%, especially hair dye), and drugs/medications/alcoholic beverages (9.1%). Only 2.3% of positive reactions were linked to occupation. Positive reactions to SD occurred in 2.7% of tested patients. Reactions were often clinically relevant and linked to personal care products and drugs/medications/alcoholic beverages.
Sections du résumé
BACKGROUND
BACKGROUND
Sodium disulfite (SD), also known as sodium metabisulfite, is an increasingly recognized cause of allergic contact dermatitis.
OBJECTIVES
OBJECTIVE
The objective of this work was to characterize individuals with positive patch test reactions to SD as well as analyse reaction strength, clinical relevance, and sources.
METHODS
METHODS
This is a retrospective analysis of patients patch tested with SD (1% petrolatum) by the North American Contact Dermatitis Group (NACDG), 2017 to 2018.
RESULTS
RESULTS
Of 4885 patients patch tested with SD, 132 (2.7%) had a positive reaction. Common primary anatomic sites of dermatitis were face (28.8%), hands (20.5%), and a scattered/generalized distribution (13.6%). Compared with SD-negative patients, SD-positive patients were more likely male (odds ratio 2.81, 95% confidence interval 1.98-4.00) and/or over 40 years (odds ratio 1.95, 95% confidence interval 1.30-2.94). Reactions were most commonly + (50.4%) or ++ (34.1%); 65.2% were considered currently relevant. About 15.2% were definitively confirmed in sources, commonly personal care products (18.9%, especially hair dye), and drugs/medications/alcoholic beverages (9.1%). Only 2.3% of positive reactions were linked to occupation.
CONCLUSIONS
CONCLUSIONS
Positive reactions to SD occurred in 2.7% of tested patients. Reactions were often clinically relevant and linked to personal care products and drugs/medications/alcoholic beverages.
Substances chimiques
Cosmetics
0
Sulfites
0
sodium metabisulfite
4VON5FNS3C
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
285-296Informations de copyright
© 2021 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.
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