The Innate Immune Response Characterizes Posterior Reversible Encephalopathy Syndrome.
Adaptive Immunity
/ immunology
Adult
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Female
Humans
Immunity, Innate
/ immunology
Leukoencephalopathy, Progressive Multifocal
/ diagnosis
Lipopolysaccharide Receptors
/ immunology
Male
Middle Aged
Monocytes
/ immunology
Posterior Leukoencephalopathy Syndrome
/ diagnosis
Receptors, IgG
/ immunology
Retrospective Studies
PRES
flow cytometry
immune cells
posterior reversible encephalopathy syndrome
Journal
Journal of clinical immunology
ISSN: 1573-2592
Titre abrégé: J Clin Immunol
Pays: Netherlands
ID NLM: 8102137
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
06
01
2021
accepted:
30
03
2021
pubmed:
13
4
2021
medline:
4
2
2022
entrez:
12
4
2021
Statut:
ppublish
Résumé
While posterior reversible encephalopathy syndrome (PRES) is often characterized by an inflammatory cerebrospinal-fluid (CSF) profile, knowledge of immune cell patterns in PRES is lacking. Thus, we retrospectively characterized CSF and peripheral blood (PB) from 15 PRES patients, which we analyzed by multidimensional flow cytometry (FC). Results were compared to 72 controls, as well as to 9 patients with progressive multifocal leukoencephalopathy (PML, as a relevant differential diagnosis) and 15 multiple sclerosis patients (MS, as a classical neuroinflammatory disorder), respectively. Total protein level in CSF from PRES patients was elevated compared to that in controls, but not to MS and PML. In-depth FC analysis revealed no differences for adaptive immune cells (B cells, plasma cells, CD4
Identifiants
pubmed: 33844127
doi: 10.1007/s10875-021-01033-3
pii: 10.1007/s10875-021-01033-3
pmc: PMC8310851
doi:
Substances chimiques
Lipopolysaccharide Receptors
0
Receptors, IgG
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1229-1240Informations de copyright
© 2021. The Author(s).
Références
BMC Immunol. 2010 Jun 21;11:30
pubmed: 20565954
J Neuroimaging. 2004 Apr;14(2):89-96
pubmed: 15095552
BMJ Open. 2019 Feb 13;9(2):e025348
pubmed: 30765408
Sci Rep. 2020 Mar 10;10(1):4397
pubmed: 32157175
Sci Rep. 2015 Sep 11;5:13886
pubmed: 26358827
Exp Mol Med. 2019 Apr 25;51(4):1-12
pubmed: 31023999
Acta Neuropsychiatr. 2009 Jun;21 Suppl 2:58-61
pubmed: 25384872
AJNR Am J Neuroradiol. 2008 Jun;29(6):1043-9
pubmed: 18403560
J Am Coll Cardiol. 2013 Oct 22;62(17):1541-51
pubmed: 23973684
J Exp Med. 2014 Aug 25;211(9):1833-46
pubmed: 25135296
Sci Rep. 2016 Dec 19;6:39483
pubmed: 27991581
Mayo Clin Proc. 2010 May;85(5):427-32
pubmed: 20435835
AJNR Am J Neuroradiol. 2008 Jun;29(6):1036-42
pubmed: 18356474
Front Immunol. 2019 Apr 12;10:726
pubmed: 31031747
J Neurol. 2016 Jan;263(1):30-4
pubmed: 26477022
Ann Transl Med. 2019 Mar;7(Suppl 1):S19
pubmed: 31032300
Arch Dermatol. 2011 Oct;147(10):1197-202
pubmed: 21680761
Sci Rep. 2020 Jan 22;10(1):947
pubmed: 31969629
J Neurol. 1987 Jan;234(1):19-22
pubmed: 2950211
Arthritis Rheum. 2012 Mar;64(3):671-7
pubmed: 22006178
Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5665-74
pubmed: 27601660
Immunol Res. 2012 Sep;53(1-3):41-57
pubmed: 22430559
Proc Natl Acad Sci U S A. 2016 May 24;113(21):E2973-82
pubmed: 27162345
Neurohospitalist. 2019 Apr;9(2):58-64
pubmed: 30915182
Mult Scler Relat Disord. 2014 Nov;3(6):728-31
pubmed: 25891552
Mayo Clin Proc. 2015 Oct;90(10):1366-71
pubmed: 26349950
Infect Immun. 2014 Nov;82(11):4438-46
pubmed: 25114121
J Mol Med (Berl). 2015 Sep;93(9):963-71
pubmed: 26175090