Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
entrez:
12
4
2021
pubmed:
13
4
2021
medline:
26
11
2021
Statut:
ppublish
Résumé
Inconsistent associations between long-term exposure to particles with an aerodynamic diameter We investigated the associations between long-term exposure to We pooled data from eight European cohorts with 323,782 participants, average age 49 y at baseline (1985-2005). Residential exposure to 2010 annual average concentration of eight We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. All SLR-modeled components were statistically significantly associated with natural-cause mortality in single-pollutant models with hazard ratios (HRs) from 1.05 to 1.27. Similar HRs were observed for RF-modeled Cu, Fe, K, S, V, and Zn with wider confidence intervals (CIs). HRs for SLR-modeled Ni, S, Si, V, and Zn remained above unity and (almost) significant after adjustment for both Long-term exposure to V in
Sections du résumé
BACKGROUND
Inconsistent associations between long-term exposure to particles with an aerodynamic diameter
OBJECTIVES
We investigated the associations between long-term exposure to
METHODS
We pooled data from eight European cohorts with 323,782 participants, average age 49 y at baseline (1985-2005). Residential exposure to 2010 annual average concentration of eight
RESULTS
We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. All SLR-modeled components were statistically significantly associated with natural-cause mortality in single-pollutant models with hazard ratios (HRs) from 1.05 to 1.27. Similar HRs were observed for RF-modeled Cu, Fe, K, S, V, and Zn with wider confidence intervals (CIs). HRs for SLR-modeled Ni, S, Si, V, and Zn remained above unity and (almost) significant after adjustment for both
CONCLUSION
Long-term exposure to V in
Identifiants
pubmed: 33844598
doi: 10.1289/EHP8368
pmc: PMC8041432
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
47009Subventions
Organisme : Medical Research Council
ID : MR/S019669/1
Pays : United Kingdom
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