The Human Islet: Mini-Organ With Mega-Impact.
diabetes
glucagon
glucose
insulin
islet
α cell
β cell
Journal
Endocrine reviews
ISSN: 1945-7189
Titre abrégé: Endocr Rev
Pays: United States
ID NLM: 8006258
Informations de publication
Date de publication:
28 09 2021
28 09 2021
Historique:
received:
11
11
2020
pubmed:
13
4
2021
medline:
15
4
2022
entrez:
12
4
2021
Statut:
ppublish
Résumé
This review focuses on the human pancreatic islet-including its structure, cell composition, development, function, and dysfunction. After providing a historical timeline of key discoveries about human islets over the past century, we describe new research approaches and technologies that are being used to study human islets and how these are providing insight into human islet physiology and pathophysiology. We also describe changes or adaptations in human islets in response to physiologic challenges such as pregnancy, aging, and insulin resistance and discuss islet changes in human diabetes of many forms. We outline current and future interventions being developed to protect, restore, or replace human islets. The review also highlights unresolved questions about human islets and proposes areas where additional research on human islets is needed.
Identifiants
pubmed: 33844836
pii: 6223906
doi: 10.1210/endrev/bnab010
pmc: PMC8476939
doi:
Substances chimiques
Insulin
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
605-657Subventions
Organisme : NIDDK NIH HHS
ID : UC4 DK104211
Pays : United States
Organisme : NIDDK NIH HHS
ID : U24 DK098085
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK112232
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK089572
Pays : United States
Organisme : NIDDK NIH HHS
ID : R33 DK066636
Pays : United States
Organisme : NIDDK NIH HHS
ID : R24 DK106755
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK097829
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK123716
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK098085
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK108120
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK072473
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK120456
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007347
Pays : United States
Organisme : BLRD VA
ID : I01 BX000666
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK094199
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020593
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK123743
Pays : United States
Organisme : NIDDK NIH HHS
ID : F30 DK118830
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK117147
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK066636
Pays : United States
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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