GPR55 regulates the responsiveness to, but does not dimerise with, α
Adrenergic alpha-1 Receptor Agonists
/ pharmacology
Animals
Animals, Newborn
CHO Cells
Cells, Cultured
Cricetinae
Cricetulus
Female
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Organ Culture Techniques
Pregnancy
Protein Multimerization
/ drug effects
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, alpha-1
/ genetics
Receptors, Cannabinoid
/ deficiency
Cardiac function
GPR55
Receptor crosstalk
α(1A)-adrenoceptor
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
28
01
2021
revised:
26
03
2021
accepted:
06
04
2021
pubmed:
13
4
2021
medline:
15
9
2021
entrez:
12
4
2021
Statut:
ppublish
Résumé
Emerging evidence suggests that G protein coupled receptor 55 (GPR55) may influence adrenoceptor function/activity in the cardiovascular system. Whether this reflects direct interaction (dimerization) between receptors or signalling crosstalk has not been investigated. This study explored the interaction between GPR55 and the alpha 1A-adrenoceptor (α
Identifiants
pubmed: 33844984
pii: S0006-2952(21)00156-8
doi: 10.1016/j.bcp.2021.114560
pii:
doi:
Substances chimiques
Adrenergic alpha-1 Receptor Agonists
0
GPR55 protein, mouse
0
Receptors, Adrenergic, alpha-1
0
Receptors, Cannabinoid
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
114560Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.