Is hyaluronic acid the perfect excipient for the pharmaceutical need?
Hyaluronic acid
Modification
Mucoadhesion
Polymer
Structure
Thiomers
Tissue
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
15 May 2021
15 May 2021
Historique:
received:
09
02
2021
revised:
31
03
2021
accepted:
05
04
2021
pubmed:
13
4
2021
medline:
22
6
2021
entrez:
12
4
2021
Statut:
ppublish
Résumé
Hyaluronic acid has become an interesting and important polymer as an excipient for pharmaceutical products due to its beneficial properties, like solubility, biocompatibility and biodegradation. To improve the properties of hyaluronic acid, different possibilities for chemical modifications are presented, and the opportunities as novel systems for drug delivery are discussed. This review gives an overview over the production of hyaluronic acid, the possibilities of its chemical modification and the current state of in vitro and in vivo research. Furthermore, market approved and commercially available products are reviewed and derivatives undergoing clinical trials and applying for market approval are shown. In particular, hyaluronic acid has been studied for different administrations in rheumatology, ophthalmology, local anesthetics, cancer treatment and bioengineering of tissues. The present work concludes with perspectives for future administration of pharmaceuticals based on hyaluronic acid.
Identifiants
pubmed: 33845151
pii: S0378-5173(21)00394-X
doi: 10.1016/j.ijpharm.2021.120589
pii:
doi:
Substances chimiques
Excipients
0
Pharmaceutical Preparations
0
Polymers
0
Hyaluronic Acid
9004-61-9
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
120589Informations de copyright
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