Upregulation of antioxidant and autophagy pathways via NRF2 activation protects spinal cord neurons from ozone damage.
Animals
Antioxidant Response Elements
Antioxidants
/ pharmacology
Autophagy
/ drug effects
Cell Death
Cell Survival
/ drug effects
Heme Oxygenase-1
/ metabolism
Hydroquinones
Male
Microtubule-Associated Proteins
NF-E2-Related Factor 2
/ genetics
Neurons
/ metabolism
Ozone
/ pharmacology
Protective Agents
/ pharmacology
Rats
Rats, Wistar
Spinal Cord
/ metabolism
Up-Regulation
/ drug effects
autophagy
NRF2
ozone
spinal cord neurons
tBHQ
Journal
Molecular medicine reports
ISSN: 1791-3004
Titre abrégé: Mol Med Rep
Pays: Greece
ID NLM: 101475259
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
23
09
2020
accepted:
09
03
2021
entrez:
13
4
2021
pubmed:
14
4
2021
medline:
21
10
2021
Statut:
ppublish
Résumé
Ozone therapy can relieve multiple types of pain but exhibits potential neurotoxicity, the mechanism of which is unclear. The present study aimed to identify the role of nuclear factor (erythroid‑derived‑2)‑related 2 (NRF2) in preventing spinal cord injury caused by ozone overdose. Primary neuronal cells were extracted from newborn Wistar rats and authenticated by immunofluorescence using anti‑microtubule‑associated protein 2 as a cell type‑specific marker. Cell viability assay with different ozone concentrations (0, 10, 20, 30 and 40
Identifiants
pubmed: 33846774
doi: 10.3892/mmr.2021.12067
pii: 428
pmc: PMC8047762
doi:
pii:
Substances chimiques
Antioxidants
0
Hydroquinones
0
MAP2 protein, rat
0
Microtubule-Associated Proteins
0
NF-E2-Related Factor 2
0
Protective Agents
0
Ozone
66H7ZZK23N
2-tert-butylhydroquinone
C12674942B
Heme Oxygenase-1
EC 1.14.14.18
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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