Characterization of an L-α,β-diaminopropionic acid polymer with comb-like structure isolated from a poly(ε-L-lysine)-producing Streptomyces sp.
Antimicrobial activity
Comb-like structure
L-α,β-Diaminopropionic acid
Poly(amino acid)s
Poly(ε-L-lysine)
Streptomyces
Journal
Applied microbiology and biotechnology
ISSN: 1432-0614
Titre abrégé: Appl Microbiol Biotechnol
Pays: Germany
ID NLM: 8406612
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
29
01
2021
accepted:
23
03
2021
revised:
16
03
2021
pubmed:
14
4
2021
medline:
15
5
2021
entrez:
13
4
2021
Statut:
ppublish
Résumé
Polymers of basic amino acids function as polycationic compounds under physiological conditions and exhibit intriguing biological properties, such as antimicrobial and antiviral activities, immunopotentiating ability, and DNA-binding activity. Poly(ε-L-lysine) (ε-PL) produced by some strains of Streptomyces spp. is a cationic homopolymer of L-lysine linking between ε-amino and α-carboxylic acid functional groups and has been used as a food preservative based on its biocompatibility and biodegradability. An ε-PL-producing strain of Streptomyces sp. USE-33 was found to secrete a novel polycationic substance into its culture broth along with ε-PL. High-performance liquid chromatography analyses and one- and two-dimensional
Identifiants
pubmed: 33846822
doi: 10.1007/s00253-021-11257-3
pii: 10.1007/s00253-021-11257-3
doi:
Substances chimiques
Polymers
0
beta-Alanine
11P2JDE17B
Polylysine
25104-18-1
2,3-diaminopropionic acid
8908T5BN6R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3145-3157Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K05798
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