The clinical characteristics and predictors of severe digital ischemia in patients with anti-aminoacyl transfer RNA synthetase antibodies.
Raynaud's phenomenon
aminoacyl transfer RNA synthetase
gangrene
necrosis
ulcer
Journal
The Journal of dermatology
ISSN: 1346-8138
Titre abrégé: J Dermatol
Pays: England
ID NLM: 7600545
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
12
03
2021
received:
30
01
2021
accepted:
19
03
2021
pubmed:
14
4
2021
medline:
6
7
2021
entrez:
13
4
2021
Statut:
ppublish
Résumé
Severe digital ischemia (SDI), which presents with digital ulcers, necrosis, or gangrene, has been reported to be a rare manifestation of anti-aminoacyl transfer RNA synthetase (ARS) antibody-positive polymyositis/dermatomyositis or anti-synthetase syndrome. A retrospective study was conducted between 2009 and 2020 at our department to investigate the clinical features of anti-ARS antibody-positive patients with SDI and identify their predictors. A total of 46 patients who were positive for anti-ARS antibody were included, four of whom (8.7%) presented with SDI. The characteristics of the patients with SDI were as follows: the median age was 74 years, with 75% being female; anti-Jo-1 antibody, Raynaud's phenomenon, interstitial lung disease, and myositis were observed in two (50%), four (100%), four (100%), and three patients (75%), respectively. Next, we reviewed the literature of anti-ARS antibody-positive patients with SDI and investigated the predictors of SDI by analyzing a total of 51 patients, including the previously reported five patients with SDI. Multivariable analyses revealed that Raynaud's phenomenon and myositis independently predicted the development of SDI in patients with anti-ARS antibody. In conclusion, digital ulcers, necrosis, or gangrene seem to be more common presentations in our study, and Raynaud's phenomenon and myositis can predict the complications of SDI in anti-ARS antibody-positive patients.
Identifiants
pubmed: 33847003
doi: 10.1111/1346-8138.15884
doi:
Substances chimiques
Autoantibodies
0
Amino Acyl-tRNA Synthetases
EC 6.1.1.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1044-1051Subventions
Organisme : JSPS KAKENHI
ID : 19K08908
Organisme : JSPS KAKENHI
ID : 19K18499
Organisme : JSPS KAKENHI
ID : 19K07940
Informations de copyright
© 2021 Japanese Dermatological Association.
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