What's in a Name? Drug Nomenclature and Medicinal Chemistry Trends using INN Publications.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
22 04 2021
22 04 2021
Historique:
pubmed:
14
4
2021
medline:
17
6
2021
entrez:
13
4
2021
Statut:
ppublish
Résumé
The World Health Organization assigns international nonproprietary names (INN), also known as common names, to compounds upon request from drug developers. Structures of INNs are publicly available and represent a source, albeit underused, to understand trends in drug research and development. Here, we explain how a common drug name is composed and analyze chemical entities from 2000 to 2021. In the analysis, we describe some changes that intertwine chemical structure, newer therapeutic targets (e.g., kinases), including a significant increase in the use of fluorine and of heterocycles, and some other evolutionary modifications, such as the progressive increase in molecular weight. Alongside these, small signs of change can be spotted, such as the rise in spirocyclic scaffolds and small rings and the emergence of unconventional structural moieties that might forecast the future to come.
Identifiants
pubmed: 33847110
doi: 10.1021/acs.jmedchem.1c00181
pmc: PMC8154580
doi:
Substances chimiques
Heterocyclic Compounds
0
Pharmaceutical Preparations
0
Fluorine
284SYP0193
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4410-4429Références
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