New methods to decrypt emerging macropinosome functions during the host-pathogen crosstalk.
Journal
Cellular microbiology
ISSN: 1462-5822
Titre abrégé: Cell Microbiol
Pays: India
ID NLM: 100883691
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
30
03
2021
received:
03
02
2021
accepted:
31
03
2021
pubmed:
14
4
2021
medline:
1
1
2022
entrez:
13
4
2021
Statut:
ppublish
Résumé
Large volumes of liquid and other materials from the extracellular environment are internalised by eukaryotic cells via an endocytic process called macropinocytosis. It is now recognised that this fundamental and evolutionarily conserved pathway is hijacked by numerous intracellular pathogens as an entry portal to the host cell interior. Yet, an increasing number of additional cellular functions of macropinosomes in pathologic processes have been reported beyond this role for fluid internalisation. It emerges that the identity of macropinosomes can vary hugely and change rapidly during their lifetime. A deeper understanding of this important multi-faceted compartment is based on novel methods for their investigation. These methods are either imaging-based for the tracking of macropinosome dynamics, or they provide the means to extract macropinosomes at high purity for comprehensive proteomic analyses. Here, we portray these new approaches for the investigation of macropinosomes. We document how these method developments have provided insights for a new understanding of the intracellular lifestyle of the bacterial pathogens Shigella and Salmonella. We suggest that a systematic complete characterisation of macropinosome subversion with these approaches during other infection processes and pathologies will be highly beneficial for our understanding of the underlying cellular and molecular processes.
Identifiants
pubmed: 33848057
doi: 10.1111/cmi.13342
pmc: PMC8365644
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13342Subventions
Organisme : Agence Nationale de la Recherche
ID : AutoHostPath
Organisme : Agence Nationale de la Recherche
ID : HBPSensing
Organisme : Agence Nationale de la Recherche
ID : StopBugEntry
Organisme : H2020: European Research Council
ID : CoG EndoSubvert
Organisme : Fondation pour la Recherche Médicale
ID : FDT20170436843
Organisme : Fondation pour la Recherche Médicale
ID : SPF20160936275
Informations de copyright
© 2021 The Authors. Cellular Microbiology published by John Wiley & Sons Ltd.
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