Evolution of the gross tumour volume extent during radiotherapy for glioblastomas.
Adaptive radiotherapy
Glioblastoma
Magnetic resonance imaging
Prospective study
Journal
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
ISSN: 1879-0887
Titre abrégé: Radiother Oncol
Pays: Ireland
ID NLM: 8407192
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
16
10
2020
revised:
05
03
2021
accepted:
06
04
2021
pubmed:
14
4
2021
medline:
28
7
2021
entrez:
13
4
2021
Statut:
ppublish
Résumé
Tumour growth during radiotherapy may lead to geographical misses of the target volume. This study investigates the evolution of the tumour extent and evaluates the need for plan adaptation to ensure dose coverage of the target in glioblastoma patients. The prospective study included 29 patients referred for 59.4 Gy in 33 fractions. Magnetic resonance imaging (MRI) was performed at the time of treatment planning, at fraction 10, 20, 30, and three weeks after the end of radiotherapy. The gross tumour volume (GTV) was defined as the T1w contrast-enhanced region plus the surgical cavity on each MRI set. The relative GTV volume and the maximum distance (D Dose coverage of the GTV during radiotherapy was not compromised, and none of the radiotherapy plans was adapted. The median D Large variations in the GTV extent were observed, and changes often occurred early in the treatment. Plan adaptation for geographical misses was not performed in our cohort due to sufficient CTV margins.
Sections du résumé
BACKGROUND AND PURPOSE
Tumour growth during radiotherapy may lead to geographical misses of the target volume. This study investigates the evolution of the tumour extent and evaluates the need for plan adaptation to ensure dose coverage of the target in glioblastoma patients.
MATERIALS AND METHODS
The prospective study included 29 patients referred for 59.4 Gy in 33 fractions. Magnetic resonance imaging (MRI) was performed at the time of treatment planning, at fraction 10, 20, 30, and three weeks after the end of radiotherapy. The gross tumour volume (GTV) was defined as the T1w contrast-enhanced region plus the surgical cavity on each MRI set. The relative GTV volume and the maximum distance (D
RESULTS
Dose coverage of the GTV during radiotherapy was not compromised, and none of the radiotherapy plans was adapted. The median D
CONCLUSION
Large variations in the GTV extent were observed, and changes often occurred early in the treatment. Plan adaptation for geographical misses was not performed in our cohort due to sufficient CTV margins.
Identifiants
pubmed: 33848564
pii: S0167-8140(21)06182-X
doi: 10.1016/j.radonc.2021.04.001
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
40-46Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.