Novel 1,2,3-triazole-tethered Pam

Adjuvants, Immunologic / chemistry Cell Line Dose-Response Relationship, Drug Humans Immunity, Cellular / drug effects Molecular Structure Structure-Activity Relationship Toll-Like Receptor 2 / agonists Triazoles / chemistry Vaccines / chemistry
Adjuvant CD4 CD8 Click chemistry HBsAg IgG Pam(3)CAG-triazole conjugate TLR-2

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
06 2021
Historique:
received: 08 12 2020
revised: 04 03 2021
accepted: 16 03 2021
pubmed: 14 4 2021
medline: 15 10 2021
entrez: 13 4 2021
Statut: ppublish

Résumé

A focused library of water soluble 1,2,3-triazole tethered glycopeptide conjugates derived from variety of azido-monosaccharides and aliphatic azido-alcohols were synthesized through manipulation at the C-terminus of Pam

Identifiants

DOI: 10.1016/j.bioorg.2021.104838 PMID: 33848722
pubmed: 33848722
pii: S0045-2068(21)00215-7
doi: 10.1016/j.bioorg.2021.104838
pii:
doi:

Substances chimiques

Adjuvants, Immunologic 0
Toll-Like Receptor 2 0
Triazoles 0
Vaccines 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

104838

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Tukaram B Mhamane (TB)

Vaccine Immunology Laboratory, OSPC Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201 002, India.

Shainy Sambyal (S)

Vaccine Immunology Laboratory, OSPC Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201 002, India.

Sravanthi Vemireddy (S)

Vaccine Immunology Laboratory, OSPC Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201 002, India.

Imran A Khan (IA)

Department of Chemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi.

Syed Shafi (S)

Department of Chemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi.

Sampath Kumar Halmuthur M (SK)

Vaccine Immunology Laboratory, OSPC Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201 002, India. Electronic address: sampath.iict@gov.in.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Adjuvants immunologiques › Novel 1,2,3-triazole-tethered Pam
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Novel 1,2,3-triazole-tethered Pam
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Novel 1,2,3-triazole-tethered Pam
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel 1,2,3-triazole-tethered Pam
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › Novel 1,2,3-triazole-tethered Pam
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Novel 1,2,3-triazole-tethered Pam
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Novel 1,2,3-triazole-tethered Pam
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de reconnaissance de motifs moléculaires › Récepteurs de type Toll › Récepteur de type Toll-2 › Novel 1,2,3-triazole-tethered Pam
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Novel 1,2,3-triazole-tethered Pam
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Novel 1,2,3-triazole-tethered Pam