Amygdala hyperconnectivity in the paranoid state: A transdiagnostic study.
Amygdala
Functional connectivity
Paranoia
Prefrontal cortex
Transdiagnostic
Journal
Journal of psychiatric research
ISSN: 1879-1379
Titre abrégé: J Psychiatr Res
Pays: England
ID NLM: 0376331
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
05
01
2021
revised:
23
03
2021
accepted:
25
03
2021
pubmed:
14
4
2021
medline:
6
7
2021
entrez:
13
4
2021
Statut:
ppublish
Résumé
Paranoia significantly contributes to social impairments across clinical diagnoses, and amygdala dysfunction has been identified as a neurobiological marker of paranoia among individuals with schizophrenia. Therefore, we aimed to investigate amygdala functional connectivity (FC) in paranoia across diagnoses. Forty-five patients with recent history of clinically significant paranoid ideation and a current DSM-5 diagnosis of any disorder underwent resting-state functional magnetic resonance imaging either in a paranoid (N = 23) or non-paranoid (N = 22) state. Amygdala FC were compared between paranoid and non-paranoid patients. Supplemental correlation analyses between amygdala FC and paranoia score were performed separately in patients and a non-equivalent healthy control (HC; N = 60) group. Increased FC was found between right amygdala and the prefrontal cortex (PFC) [bilateral medial superior frontal gyrus, anterior cingulate, medial frontal gyrus, the triangular part and the opercular part of the inferior frontal gyrus (IFG); right orbital part of IFG], the frontal cortex (bilateral median cingulate, left precentral gyrus), and subcortical areas (right insula) in the paranoid group compared with the non-paranoid group. No significant between-group differences were observed in left amygdala FC. FC between right amygdala and PFC and frontal cortex was positively correlated with paranoia in patient and HC groups. Paranoia is associated with right amygdala hyperconnectivity with PFC, frontal cortex, and insula. This hyperconnectivity was evident regardless of diagnosis and therefore identify a likely transdiagnostic neural mechanism, which may help to identify treatment targets that could potentially improve the social functioning of individuals with clinical diagnoses.
Sections du résumé
BACKGROUND
Paranoia significantly contributes to social impairments across clinical diagnoses, and amygdala dysfunction has been identified as a neurobiological marker of paranoia among individuals with schizophrenia. Therefore, we aimed to investigate amygdala functional connectivity (FC) in paranoia across diagnoses.
METHODS
Forty-five patients with recent history of clinically significant paranoid ideation and a current DSM-5 diagnosis of any disorder underwent resting-state functional magnetic resonance imaging either in a paranoid (N = 23) or non-paranoid (N = 22) state. Amygdala FC were compared between paranoid and non-paranoid patients. Supplemental correlation analyses between amygdala FC and paranoia score were performed separately in patients and a non-equivalent healthy control (HC; N = 60) group.
RESULTS
Increased FC was found between right amygdala and the prefrontal cortex (PFC) [bilateral medial superior frontal gyrus, anterior cingulate, medial frontal gyrus, the triangular part and the opercular part of the inferior frontal gyrus (IFG); right orbital part of IFG], the frontal cortex (bilateral median cingulate, left precentral gyrus), and subcortical areas (right insula) in the paranoid group compared with the non-paranoid group. No significant between-group differences were observed in left amygdala FC. FC between right amygdala and PFC and frontal cortex was positively correlated with paranoia in patient and HC groups.
CONCLUSION
Paranoia is associated with right amygdala hyperconnectivity with PFC, frontal cortex, and insula. This hyperconnectivity was evident regardless of diagnosis and therefore identify a likely transdiagnostic neural mechanism, which may help to identify treatment targets that could potentially improve the social functioning of individuals with clinical diagnoses.
Identifiants
pubmed: 33848967
pii: S0022-3956(21)00201-6
doi: 10.1016/j.jpsychires.2021.03.049
pmc: PMC8192453
mid: NIHMS1688810
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
117-124Subventions
Organisme : NIMH NIH HHS
ID : R21 MH112930
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Références
J Pers Soc Psychol. 1992 Jan;62(1):129-38
pubmed: 1538311
Nat Rev Neurosci. 2015 Jan;16(1):55-61
pubmed: 25406711
Neuroinformatics. 2016 Jul;14(3):339-51
pubmed: 27075850
Schizophr Bull. 2018 Jan 13;44(1):101-113
pubmed: 28369611
Mol Psychiatry. 2001 Jan;6(1):13-34
pubmed: 11244481
Biol Psychiatry. 2013 Jan 15;73(2):127-35
pubmed: 22858151
Biol Psychiatry. 2015 Feb 15;77(4):394-403
pubmed: 24882566
Br J Clin Psychol. 2006 Mar;45(Pt 1):19-31
pubmed: 16480564
Comput Biomed Res. 1996 Jun;29(3):162-73
pubmed: 8812068
Neurosci Biobehav Rev. 2010 Mar;34(3):468-86
pubmed: 19772872
Behav Neurosci. 2004 Feb;118(1):15-23
pubmed: 14979779
Neuroimage. 2015 May 15;112:14-29
pubmed: 25731998
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Schizophr Bull. 2014 Mar;40(2):469-77
pubmed: 23599250
Neuroimage. 2009 Oct 1;47(4):1408-16
pubmed: 19442749
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
Psychol Med. 2018 Sep;48(12):1985-1992
pubmed: 29328019
Hum Brain Mapp. 2019 Jun 15;40(9):2723-2735
pubmed: 30829454
Psychiatry Res. 2007 May 15;155(1):29-44
pubmed: 17398080
Neuroimage. 2009 Feb 1;44(3):893-905
pubmed: 18976716
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4734-9
pubmed: 20176931
J Clin Psychiatry. 2003 Jun;64(6):663-7
pubmed: 12823080
Eur Arch Psychiatry Clin Neurosci. 2010 Feb;260(1):69-76
pubmed: 19452191
Nature. 1998 Jun 4;393(6684):467-70
pubmed: 9624001
Schizophr Res. 2017 Dec;190:96-101
pubmed: 28320578
Schizophr Bull. 1987;13(2):261-76
pubmed: 3616518
J Am Acad Child Adolesc Psychiatry. 2018 Mar;57(3):166-174
pubmed: 29496125
Science. 2003 Oct 10;302(5643):290-2
pubmed: 14551436
Schizophr Res. 2017 May;183:102-109
pubmed: 28291690
Neuron. 2008 Sep 25;59(6):1037-50
pubmed: 18817740
Psychol Med. 1986 Nov;16(4):909-28
pubmed: 3493497
Arch Gen Psychiatry. 2009 Mar;66(3):236-47
pubmed: 19255373
Neuroimage. 2006 Dec;33(4):1093-103
pubmed: 17011792
Biol Psychiatry. 2003 Apr 1;53(7):601-8
pubmed: 12679238
Neuropsychologia. 2011 Mar;49(4):602-11
pubmed: 20920512
Neuroimage. 2012 Sep;62(3):1575-81
pubmed: 22634856
Am J Psychiatry. 2015 Aug 1;172(8):784-92
pubmed: 25815418
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
Neuroimage. 2014 Nov 15;102 Pt 2:938-44
pubmed: 24879924
Schizophr Res. 2008 Feb;99(1-3):164-75
pubmed: 18053686
Schizophr Res. 2010 Mar;117(1):13-20
pubmed: 19854028
Bipolar Disord. 2012 Mar;14(2):175-84
pubmed: 22420593
Schizophr Res Cogn. 2016 Mar;3:33-38
pubmed: 27990352
Cereb Cortex. 2011 Jul;21(7):1667-73
pubmed: 21127016
Schizophr Bull. 2007 Jul;33(4):971-81
pubmed: 17519393
Nature. 1998 Jun 4;393(6684):470-4
pubmed: 9624002
J Psychiatry Neurosci. 2012 Jan;37(1):17-27
pubmed: 21693094
Schizophr Res. 2007 Sep;95(1-3):30-8
pubmed: 17669627
Clin Psychol Rev. 2007 May;27(4):425-57
pubmed: 17258852
Am J Psychiatry. 2004 Mar;161(3):480-9
pubmed: 14992974
Schizophr Res. 2007 Dec;97(1-3):194-205
pubmed: 17628434
Arch Gen Psychiatry. 2000 Jun;57(6):593-600
pubmed: 10839338
Proc Natl Acad Sci U S A. 2009 Oct 13;106(41):17558-63
pubmed: 19805061
Arch Gen Psychiatry. 2010 Aug;67(8):783-92
pubmed: 20679586