Central human B cell tolerance manifests with a distinctive cell phenotype and is enforced via CXCR4 signaling in hu-mice.
Animals
Autoantibodies
/ metabolism
Autoantigens
/ immunology
Autoimmunity
/ immunology
B-Lymphocytes
/ immunology
Bone Marrow
/ metabolism
Bone Marrow Cells
/ cytology
Cell Differentiation
/ genetics
Central Tolerance
/ immunology
Female
Humans
Immune Tolerance
/ genetics
Infant, Newborn
Male
Mice
Mice, Inbred BALB C
Mice, Transgenic
Phenotype
Precursor Cells, B-Lymphoid
/ metabolism
Receptors, Antigen, B-Cell
/ metabolism
Receptors, CXCR4
/ immunology
Signal Transduction
/ genetics
B cell tolerance
CXCR4
autoimmunity
hu-mice
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
20 04 2021
20 04 2021
Historique:
entrez:
14
4
2021
pubmed:
15
4
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Central B cell tolerance, the process restricting the development of many newly generated autoreactive B cells, has been intensely investigated in mouse cells while studies in humans have been hampered by the inability to phenotypically distinguish autoreactive and nonautoreactive immature B cell clones and the difficulty in accessing fresh human bone marrow samples. Using a human immune system mouse model in which all human Igκ
Identifiants
pubmed: 33850015
pii: 2021570118
doi: 10.1073/pnas.2021570118
pmc: PMC8072395
pii:
doi:
Substances chimiques
Autoantibodies
0
Autoantigens
0
CXCR4 protein, human
0
Receptors, Antigen, B-Cell
0
Receptors, CXCR4
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R21 AI131639
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI136534
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002535
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI063321
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124474
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI152535
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
J Immunol. 2003 Oct 15;171(8):4062-72
pubmed: 14530327
Nat Immunol. 2010 Aug;11(8):681-8
pubmed: 20644574
Pharmacol Res. 2020 Sep;159:105010
pubmed: 32544428
Leukemia. 2018 Jun;32(6):1445-1457
pubmed: 29483712
J Exp Med. 2019 May 6;216(5):1135-1153
pubmed: 30948496
Nat Immunol. 2004 Jun;5(6):645-50
pubmed: 15156139
Ann N Y Acad Sci. 2011 Dec;1246:1-10
pubmed: 22236425
J Exp Med. 2010 May 10;207(5):1113-24
pubmed: 20404103
Immunol Rev. 2019 Nov;292(1):90-101
pubmed: 31721234
Nature. 1995 Jan 19;373(6511):252-5
pubmed: 7816141
Nature. 1988 Aug 25;334(6184):676-82
pubmed: 3261841
J Biol Chem. 2010 Jul 16;285(29):22328-37
pubmed: 20463015
J Exp Med. 2007 Jan 22;204(1):153-60
pubmed: 17210730
J Exp Med. 2014 Dec 15;211(13):2567-81
pubmed: 25403444
Front Immunol. 2018 Apr 09;9:707
pubmed: 29686680
Cell. 2014 Apr 24;157(3):714-25
pubmed: 24766814
Immunol Rev. 2019 May;289(1):142-157
pubmed: 30977190
J Immunol. 2010 Oct 15;185(8):4570-81
pubmed: 20861359
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13224-9
pubmed: 21788504
Immunity. 2004 Jun;20(6):707-18
pubmed: 15189736
PLoS One. 2010 Sep 23;5(9):e12954
pubmed: 20886092
Nat Rev Genet. 2016 Mar;17(3):160-74
pubmed: 26907721
Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10844-9
pubmed: 9380722
Cold Spring Harb Perspect Biol. 2012 Apr 01;4(4):a007146
pubmed: 22378602
Sci Immunol. 2016;1(1):
pubmed: 27917411
J Immunol. 2002 Jan 1;168(1):87-94
pubmed: 11751950
Immunity. 1997 Dec;7(6):765-75
pubmed: 9430222
Arthritis Rheum. 2013 Apr;65(4):1085-96
pubmed: 23279883
J Exp Med. 2005 Mar 7;201(5):703-11
pubmed: 15738055
Immunol Res. 2014 May;58(2-3):179-85
pubmed: 24522698
J Immunol. 2019 May 15;202(10):2907-2923
pubmed: 30962292
Blood Adv. 2017 Dec 19;1(27):2729-2741
pubmed: 29296925
Lupus. 2011 Apr;20(5):501-6
pubmed: 21543514
J Clin Invest. 2013 Jun;123(6):2737-41
pubmed: 23676463
J Clin Invest. 2016 Jan;126(1):282-7
pubmed: 26642366
J Allergy Clin Immunol. 2013 Apr;131(4):959-71
pubmed: 23465663
Front Immunol. 2019 Dec 18;10:2970
pubmed: 31921208
Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):E2797-806
pubmed: 24958853
Nat Rev Immunol. 2003 Nov;3(11):890-9
pubmed: 14668805
Science. 2003 Sep 5;301(5638):1374-7
pubmed: 12920303
Nature. 1989 Feb 9;337(6207):562-6
pubmed: 2783762
Immunity. 1999 Apr;10(4):463-71
pubmed: 10229189
J Immunol. 2011 Dec 1;187(11):5596-605
pubmed: 22043016
Immunity. 2008 Jan;28(1):18-28
pubmed: 18199415
Nature. 2006 Mar 23;440(7083):540-4
pubmed: 16525420
J Exp Med. 2018 Oct 1;215(10):2586-2599
pubmed: 30158115
Eur J Immunol. 1994 Jan;24(1):145-51
pubmed: 8020549
J Immunol. 2007 May 15;178(10):6332-41
pubmed: 17475862
Front Immunol. 2019 Feb 19;10:203
pubmed: 30837986
PLoS One. 2010 Feb 18;5(2):e9277
pubmed: 20174580
J Immunol. 2013 Mar 1;190(5):2090-101
pubmed: 23335750
Adv Immunol. 2007;95:83-110
pubmed: 17869611
EMBO J. 1997 Jul 16;16(14):4217-25
pubmed: 9250665
Immunol Rev. 2004 Feb;197:179-91
pubmed: 14962195
J Clin Invest. 2010 Apr;120(4):1265-74
pubmed: 20237408
Clin Immunol. 2018 Oct;195:82-87
pubmed: 30075290
Int Immunol. 1993 Sep;5(9):1139-50
pubmed: 7902130
J Exp Med. 1997 Apr 21;185(8):1505-10
pubmed: 9126932
Annu Rev Immunol. 2014;32:83-119
pubmed: 24364806
J Transl Autoimmun. 2019 Nov 11;2:100021
pubmed: 32743507
Front Endocrinol (Lausanne). 2019 Aug 27;10:585
pubmed: 31507535
Immunity. 2007 Jun;26(6):715-25
pubmed: 17582344
Eur J Immunol. 1994 Jun;24(6):1345-52
pubmed: 8206094
Nature. 1991 Oct 24;353(6346):765-9
pubmed: 1944535
Eur J Immunol. 2010 Mar;40(3):688-98
pubmed: 20039302
Blood. 2005 Jun 1;105(11):4399-406
pubmed: 15692061
PLoS One. 2016 Sep 22;11(9):e0162209
pubmed: 27657694
Immunity. 2004 Apr;20(4):441-53
pubmed: 15084273
Annu Rev Immunol. 2001;19:595-621
pubmed: 11244048
Immunity. 2015 Nov 17;43(5):884-95
pubmed: 26546282
Front Immunol. 2019 Oct 18;10:2458
pubmed: 31681331
Nature. 2004 Jan 22;427(6972):355-60
pubmed: 14737169
Immunol Lett. 2016 Sep;177:6-15
pubmed: 27363619
Nat Rev Immunol. 2017 May;17(5):281-294
pubmed: 28368006
J Clin Invest. 2015 Jun;125(6):2203-10
pubmed: 25938781
J Exp Med. 2016 Jan 11;213(1):93-108
pubmed: 26694971
Blood Adv. 2017 Oct 13;1(23):2007-2018
pubmed: 29296847
Clin Immunol. 2011 Jul;140(1):102-16
pubmed: 21536497
Nat Immunol. 2019 Oct;20(10):1393-1403
pubmed: 31477919
J Exp Med. 2005 May 16;201(10):1659-67
pubmed: 15897279
Int Immunol. 2002 Jun;14(6):535-44
pubmed: 12039905
Exp Hematol. 2011 Mar;39(3):384-90
pubmed: 21168468
J Clin Invest. 2011 Sep;121(9):3635-44
pubmed: 21804190
Eur J Immunol. 1993 Mar;23(3):739-46
pubmed: 8095460