Granulomatous mastitis caused by Rickettsia species.
Anti-Bacterial Agents
/ therapeutic use
Bacteriological Techniques
Biopsy, Large-Core Needle
Female
Granulomatous Mastitis
/ diagnosis
Humans
Magnetic Resonance Imaging
Mammography
Middle Aged
Rickettsia
/ drug effects
Rickettsia Infections
/ complications
Tetracycline
/ therapeutic use
Treatment Outcome
Breast
Granulomatosis
Mastitis
Rickettsia species
Journal
Virchows Archiv : an international journal of pathology
ISSN: 1432-2307
Titre abrégé: Virchows Arch
Pays: Germany
ID NLM: 9423843
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
26
02
2021
accepted:
31
03
2021
revised:
24
03
2021
pubmed:
15
4
2021
medline:
18
1
2022
entrez:
14
4
2021
Statut:
ppublish
Résumé
Granulomatous mastitis is a rare inflammatory disease of varying etiology. Tuberculosis and cystic neutrophilic granulomatous mastitis caused by Corynebacterium are the best-established infectious examples. Despite the increasing incidence of Rickettsia-related diseases worldwide, granulomatous inflammation of breast parenchyma caused by Rickettsia has not yet been reported. We present a unique case of bilateral granulomatous mastitis documented with mammography, magnetic resonance imaging and core-needle biopsy. The rickettsial etiology of the disease was proved with specific immunohistochemistry and confirmed with DNA extraction, PCR and serology. The lesions completely resolved after a full-course tetracycline treatment. This case report widens the knowledge about the possible clinical manifestations of Rickettsia infection and adds a new bacterium to the list of etiological factors causing granulomatous mastitis.
Identifiants
pubmed: 33851237
doi: 10.1007/s00428-021-03098-2
pii: 10.1007/s00428-021-03098-2
doi:
Substances chimiques
Anti-Bacterial Agents
0
Tetracycline
F8VB5M810T
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
1091-1094Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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