Metabolic Fate and Cardiometabolic Effects of Phenolic Compounds from Red-Fleshed Apple in Hypercholesterolemic Rats: A Comparative Study with Common White-Fleshed Apple. The AppleCOR Study.
Animals
Anthocyanins
/ administration & dosage
Cardiotonic Agents
Drug Synergism
Female
Flavonoids
/ administration & dosage
Fruit
/ chemistry
Hypercholesterolemia
/ drug therapy
Male
Malus
Phenols
/ administration & dosage
Photinia
Plant Extracts
/ administration & dosage
Rats
Rats, Wistar
Species Specificity
Bowman's space
UPLC-MS/MS
anthocyanins
aortic thickness
phenolic compounds
red-fleshed apple
sustained intake
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
02
03
2021
received:
29
12
2020
pubmed:
15
4
2021
medline:
20
11
2021
entrez:
14
4
2021
Statut:
ppublish
Résumé
The present study aims to investigate the metabolic fate and the cardiometabolic effects of phenolic compounds provided by a red-fleshed apple variety biofortified in anthocyanins (ACN). Wistar rats are fed with high-fat diet (HFD) to induce hypercholesterolemia and supplemented with red-fleshed apple (HFD+R), white-fleshed apple (HFD+W), or an ACN-rich infusion from aronia fruit (HFD+A) providing matched content and profile of ACN. Plasma biochemical parameters, histological analysis, and phenol biological metabolites are determined. Plasma, urine, and feces show a significant increase of ACN metabolites after HFD+R and HFD+A, while flavan-3-ols are significantly increased after HFD+W and dihydrochalcones derivatives increased after both apples supplementation. A cardioprotective effect is observed after both apples and aronia infusion supplementation in the reduction of aortic thickness. The kidney function is improved after all supplementations and a decrease in insulin plasma concentration after both apples supplementation (HFD+R and HFD+W) is also observed. The findings support that ACN without apple matrix can induce cardioprotective effects. ACN or flavan-3-ols, together with dihydrochalcones, compose a phenolic phytocomplex in red- and white-fleshed apples, respectively, which can act synergistically in the attenuation of cardiovascular outcomes in hypercholesterolemic rats.
Identifiants
pubmed: 33851768
doi: 10.1002/mnfr.202001225
doi:
Substances chimiques
Anthocyanins
0
Cardiotonic Agents
0
Flavonoids
0
Phenols
0
Plant Extracts
0
flavan-3-ol
35HDD3NRIE
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2001225Informations de copyright
© 2021 Wiley-VCH GmbH.
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