Axillary response rates to neoadjuvant chemotherapy in breast cancer patients with advanced nodal disease.
advanced nodal disease
axillary lymph node dissection
breast cancer
sentinel lymph node biopsy
Journal
Journal of surgical oncology
ISSN: 1096-9098
Titre abrégé: J Surg Oncol
Pays: United States
ID NLM: 0222643
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
08
03
2021
received:
09
02
2021
accepted:
15
03
2021
pubmed:
15
4
2021
medline:
25
6
2021
entrez:
14
4
2021
Statut:
ppublish
Résumé
Utilization of sentinel lymph node biopsy (SLNB) in breast cancer patients with positive nodes after neoadjuvant chemotherapy (NAC) has increased. We examine axillary response rates after NAC in patients with clinical N2-3 disease to determine whether SLNB should be considered. Breast cancer patients with clinical N2-3 (AJCC 7th Edition) disease who received NAC followed by surgery were selected from our institutional tumor registry (2009-2018). Axillary response rates were assessed. Ninety-nine patients with 100 breast cancers were identified: 59 N2 (59.0%) and 41 (41.0%) N3 disease; 82 (82.0%) treated with axillary lymph node dissection (ALND) and 18 (18.0%) SLNB. The majority (99.0%) received multiagent NAC. In patients undergoing ALND, cCR was observed in 20/82 patients (24.4%), pathologic complete response (pCR) in 15 patients (18.3%), and axillary pCR in 17 patients (20.7%). In patients with a cCR, pCR was identified in 60.0% and was most common in HER2+ patients (34.6%). In this analysis of patients with clinical N2-3 disease receiving NAC, 79.3% of patients had residual nodal disease at surgery. However, 60.0% of patients with a cCR also had a pCR. This provides the foundation to consider evaluating SLNB and less extensive axillary surgery in this select group.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
25-32Subventions
Organisme : NIH HHS
ID : K12CA226330
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
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