AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity.

Adaptor Proteins, Signal Transducing / metabolism Animals Cell Line Cell Proliferation Checkpoint Kinase 1 / antagonists & inhibitors Cyclin D / metabolism Cyclin-Dependent Kinases / metabolism DNA Replication Gene Expression Regulation, Developmental Genes, Tumor Suppressor Genomic Instability Humans Mice Mice, Knockout S Phase Synthetic Lethal Mutations

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
04 2021
Historique:
received: 09 03 2020
accepted: 04 03 2021
pubmed: 16 4 2021
medline: 11 1 2022
entrez: 15 4 2021
Statut: ppublish

Résumé

Mammalian development, adult tissue homeostasis and the avoidance of severe diseases including cancer require a properly orchestrated cell cycle, as well as error-free genome maintenance. The key cell-fate decision to replicate the genome is controlled by two major signalling pathways that act in parallel-the MYC pathway and the cyclin D-cyclin-dependent kinase (CDK)-retinoblastoma protein (RB) pathway

Identifiants

DOI: 10.1038/s41586-021-03422-5 PMID: 33854232 PMC: PMC8864551
pubmed: 33854232
doi: 10.1038/s41586-021-03422-5
pii: 10.1038/s41586-021-03422-5
pmc: PMC8864551
mid: NIHMS1776644
doi:

Substances chimiques

AMBRA1 protein, human 0
Adaptor Proteins, Signal Transducing 0
Ambra1 protein, mouse 0
Cyclin D 0
Checkpoint Kinase 1 EC 2.7.11.1
Chek1 protein, mouse EC 2.7.11.1
Cyclin-Dependent Kinases EC 2.7.11.22

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

799-803

Subventions

Organisme : Medical Research Council
ID : FC001169
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001169
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R35 GM136250
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA100855
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA076584
Pays : United States
Organisme : Wellcome Trust
ID : FC001169
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : R01 CA186241
Pays : United States
Organisme : Wellcome Trust
ID : 209199/Z/17/Z
Pays : United Kingdom

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Auteurs

Emiliano Maiani (E)

Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.
Computational Biology Laboratory, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.
ORCID: 0000-0003-1432-5394

Giacomo Milletti (G)

Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.
ORCID: 0000-0003-2391-342X

Francesca Nazio (F)

Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Søs Grønbæk Holdgaard (SG)

Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.

Jirina Bartkova (J)

Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.

Salvatore Rizza (S)

Redox Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
ORCID: 0000-0001-7335-4684

Valentina Cianfanelli (V)

Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
ORCID: 0000-0002-3857-9463

Mar Lorente (M)

Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain.
Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.

Daniele Simoneschi (D)

Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.
Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA.
Howard Hughes Medical Institute, NYU Grossman School of Medicine, New York, NY, USA.
ORCID: 0000-0003-0448-4295

Miriam Di Marco (M)

Computational Biology Laboratory, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.

Pasquale D'Acunzo (P)

Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA.
Department of Psychiatry, New York University School of Medicine, New York, NY, USA.
ORCID: 0000-0001-7237-0076

Luca Di Leo (L)

Melanoma Research Team, Cell Stress and Survival Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
ORCID: 0000-0002-2419-2196

Rikke Rasmussen (R)

Brain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.

Costanza Montagna (C)

Redox Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
UniCamillus-Saint Camillus International University of Health Sciences, Rome, Italy.
Institute of Sports Medicine Copenhagen, Department of Orthopedic Surgery, Copenhagen University Hospital - Bispebjerg and Frederiksberg, Copenhagen, Denmark.

Marilena Raciti (M)

Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.

Cristiano De Stefanis (C)

Research Laboratories, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Estibaliz Gabicagogeascoa (E)

Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain.
Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.

Gergely Rona (G)

Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.
Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA.
Howard Hughes Medical Institute, NYU Grossman School of Medicine, New York, NY, USA.

Nélida Salvador (N)

Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain.
Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.

Emanuela Pupo (E)

Candiolo Cancer Institute, FPO - IRCCS, Turin, Italy.

Joanna Maria Merchut-Maya (JM)

Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
DNA Replication and Cancer Group, Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.

Colin J Daniel (CJ)

Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.

Marianna Carinci (M)

Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.

Valeriana Cesarini (V)

Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Department of Biomedical Sciences, Institute of Translational Pharmacology, National Research Council of Italy (CNR), Rome, Italy.

Alfie O'sullivan (A)

Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.
Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA.
Howard Hughes Medical Institute, NYU Grossman School of Medicine, New York, NY, USA.

Yeon-Tae Jeong (YT)

Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.
Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA.
Howard Hughes Medical Institute, NYU Grossman School of Medicine, New York, NY, USA.

Matteo Bordi (M)

Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.
ORCID: 0000-0001-8207-8546

Francesco Russo (F)

Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening, Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.

Silvia Campello (S)

Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.
ORCID: 0000-0003-0536-2484

Angela Gallo (A)

Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Giuseppe Filomeni (G)

Redox Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
ORCID: 0000-0002-2719-1412

Letizia Lanzetti (L)

Candiolo Cancer Institute, FPO - IRCCS, Turin, Italy.
Department of Oncology, University of Torino Medical School, Turin, Italy.
ORCID: 0000-0001-7541-5524

Rosalie C Sears (RC)

Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA.
ORCID: 0000-0003-1558-2413

Petra Hamerlik (P)

Brain Tumor Biology Group, Danish Cancer Society Research Center, Copenhagen, Denmark.
Department of Drug Design and Pharmacology, Copenhagen University, Copenhagen, Denmark.

Armando Bartolazzi (A)

Department of Pathology and Pathology Research Laboratory, Sant'Andrea Hospital, Rome, Italy.
ORCID: 0000-0001-7820-5127

Robert E Hynds (RE)

Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0002-2170-8791

David R Pearce (DR)

Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, UK.
ORCID: 0000-0001-8443-2924

Charles Swanton (C)

Cancer Research UK Lung Cancer Centre of Excellence, UCL Cancer Institute, University College London, London, UK.
Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, London, UK.
ORCID: 0000-0002-4299-3018

Michele Pagano (M)

Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY, USA.
Laura and Isaac Perlmutter Cancer Center, NYU Grossman School of Medicine, New York, NY, USA.
Howard Hughes Medical Institute, NYU Grossman School of Medicine, New York, NY, USA.

Guillermo Velasco (G)

Department of Biochemistry and Molecular Biology, School of Biology, Complutense University, Madrid, Spain.
Instituto de Investigación Sanitaria San Carlos (IdISSC), Madrid, Spain.
ORCID: 0000-0002-1994-2386

Elena Papaleo (E)

Computational Biology Laboratory, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.
Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Daniela De Zio (D)

Melanoma Research Team, Cell Stress and Survival Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
ORCID: 0000-0002-9454-402X

Apolinar Maya-Mendoza (A)

Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
DNA Replication and Cancer Group, Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark.
ORCID: 0000-0001-7452-9896

Franco Locatelli (F)

Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Department of Gynecology-Obstetrics and Pediatrics, Sapienza University, Rome, Italy.

Jiri Bartek (J)

Genome Integrity Unit, Danish Cancer Society Research Center, Copenhagen, Denmark. jb@cancer.dk.
Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden. jb@cancer.dk.
ORCID: 0000-0003-2013-7525

Francesco Cecconi (F)

Cell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark. cecconi@cancer.dk.
Department of Pediatric Onco-Hematology and Cell and Gene Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy. cecconi@cancer.dk.
Department of Biology, University of Rome 'Tor Vergata', Rome, Italy. cecconi@cancer.dk.
ORCID: 0000-0002-5614-4359

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Eucaryotes › Animaux › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Checkpoint kinase 1 › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Cyclines › Cycline D › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Proline-directed protein kinases › Kinases cyclines-dépendantes › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes suppresseurs de tumeur › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Phénomènes génétiques › Instabilité du génome › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Phénomènes génétiques › Réplication de l'ADN › Phase S › AMBRA1 regulates cyclin D to guard S-phase...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutations synthétiques létales › AMBRA1 regulates cyclin D to guard S-phase...