Diastolic Cardiac Function Improvement by Liraglutide Is Mainly Body Weight Reduction Dependent but Independently Contributes to B-Type Natriuretic Peptide Reduction in Patients with Type 2 Diabetes with Preserved Ejection Fraction.


Journal

Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237

Informations de publication

Date de publication:
2021
Historique:
received: 05 09 2020
revised: 15 02 2021
accepted: 06 03 2021
entrez: 15 4 2021
pubmed: 16 4 2021
medline: 23 11 2021
Statut: epublish

Résumé

A single-arm prospective study was conducted among Japanese patients with type 2 diabetes having preserved ejection fraction. The aim was to investigate (1) whether liraglutide therapy could improve B-type natriuretic peptide (BNP) levels and diastolic cardiac function assessed by the Patients with type 2 diabetes and left ventricular ejection fraction (LVEF) ≥ 40% without heart failure symptoms were enrolled, and daily injection with liraglutide (0.9 mg) was introduced. Cardiac functions were assessed by TTE before and after 26 weeks of liraglutide treatment. Diastolic cardiac function was defined as septal Thirty-one patients were analyzed. BNP and Liraglutide had favorable effects on BNP and

Identifiants

pubmed: 33855087
doi: 10.1155/2021/8838026
pmc: PMC8019623
doi:

Substances chimiques

Natriuretic Peptide, Brain 114471-18-0
Liraglutide 839I73S42A

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

8838026

Informations de copyright

Copyright © 2021 Kunimasa Yagi et al.

Déclaration de conflit d'intérêts

The authors declare that they have nothing to disclose regarding conflicts of interest concerning this manuscript except Prof. Chujo (honoraria from Eli Lilly Japan K.K., research funding from Sanofi and Novo Nordisk Pharm Ltd., and subsidies or donations from Novo Nordisk Pharm Ltd.) and Prof. Tobe (honoraria from MSD K.K., Novo Nordisk Pharm Ltd., and Kowa Pharm Co. Ltd.; subsidies or donations from Daiichi Sankyo Co. Ltd., Ono Pharm Co. Ltd., Takeda Pharm Co. Ltd., Nippon Boehringer Ingelheim Co. Ltd., MSD K.K., Mitsubishi Tanabe Pharm Co., Teijin Pharm Ltd., Eli Lilly Japan K.K., Asahi Kasei Pharm Co., The Mitsubishi Foundation, and Suntory Global Innovation Center Ltd.).

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Auteurs

Kunimasa Yagi (K)

1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.

Teruhiko Imamura (T)

2nd Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.

Hayato Tada (H)

2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.

Daisuke Chujo (D)

1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.

Jianhui Liu (J)

1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.
2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.

Yuuki Shima (Y)

2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.

Azusa Ohbatake (A)

2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.

Yukiko Miyamoto (Y)

2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.

Satoko Okazaki (S)

2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.

Naoko Ito (N)

2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.

Kaoru Nakano (K)

2nd Department of Internal Medicine, Kanazawa University Graduate School of Medical Science, 13-1 Takaramachi, Kanazawa 920-0934, Japan.

Masataka Shikata (M)

1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.

Asako Enkaku (A)

1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.

Akiko Takikawa (A)

1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.

Hisae Honoki (H)

1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.

Shiho Fujisaka (S)

1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.

Hideki Origasa (H)

Biostatistics and Clinical Epidemiology, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 934-0194, Japan.

Kazuyuki Tobe (K)

1st Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 934-0194, Japan.

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