Maternal high-sugar diet results in NMDA receptors abnormalities and cognitive impairment in rat offspring.
Animals
Cognitive Dysfunction
/ chemically induced
Dietary Sugars
/ adverse effects
Female
Gene Expression Regulation
/ drug effects
Male
Maternal Exposure
/ adverse effects
Pregnancy
Prenatal Exposure Delayed Effects
/ chemically induced
Rats
Rats, Wistar
Receptors, N-Methyl-D-Aspartate
/ genetics
Spatial Memory
/ drug effects
NMDA receptor
maternal high-sugar diet
memory impairment
miRNA
proximity ligation assay
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
26
02
2021
received:
09
12
2020
accepted:
09
03
2021
entrez:
15
4
2021
pubmed:
16
4
2021
medline:
28
7
2021
Statut:
ppublish
Résumé
Cognitive impairment affects patients suffering from various neuropsychiatric diseases, which are often accompanied by changes in the glutamatergic system. Epidemiological studies indicate that predispositions to the development of neuropsychiatric diseases may be programmed prenatally. Mother's improper diet during pregnancy and lactation may cause fetal abnormalities and, consequently, predispose to diseases in childhood and even adulthood. Considering the prevalence of obesity in developed countries, it seems important to examine the effects of diet on the behavior and physiology of future generations. We hypothesized that exposure to sugar excess in a maternal diet during pregnancy and lactation would affect memory as the NMDA receptor-related processes. Through the manipulation of the sugar amount in the maternal diet in rats, we assessed its effect on offspring's memory. Then, we evaluated if memory alterations were paralleled by molecular changes in NMDA receptors and related modulatory pathways in the prefrontal cortex and the hippocampus of adolescent and young adult female and male offspring. Behavioral studies have shown sex-related changes like impaired recognition memory in adolescent males and spatial memory in females. Molecular results confirmed an NMDA receptor hypofunction along with subunit composition abnormalities in the medial prefrontal cortex of adolescent offspring. In young adults, GluN2A-containing receptors were dominant in the medial prefrontal cortex, while in the hippocampus the GluN2B subunit contribution was elevated. In conclusion, we demonstrated that a maternal high-sugar diet can affect the memory processes in the offspring by disrupting the NMDA receptor composition and regulation in the medial prefrontal cortex and the hippocampus.
Identifiants
pubmed: 33855764
doi: 10.1096/fj.202002691R
doi:
Substances chimiques
Dietary Sugars
0
Receptors, N-Methyl-D-Aspartate
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e21547Informations de copyright
© 2021 Federation of American Societies for Experimental Biology.
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