COVID-19 and Cardiovascular Disease: From Bench to Bedside.
Angiotensin-Converting Enzyme 2
/ metabolism
Biomarkers
/ metabolism
COVID-19
/ complications
Cardiomyopathies
/ virology
Cardiovascular Diseases
/ virology
Gene Expression
Humans
Immune System
/ physiology
Myocardium
/ enzymology
Myocytes, Cardiac
/ enzymology
Neuropilin-1
/ metabolism
Platelet Activation
RNA, Messenger
/ metabolism
Renin-Angiotensin System
/ physiology
Return to Sport
Risk Factors
SARS-CoV-2
/ physiology
Spike Glycoprotein, Coronavirus
/ metabolism
Troponin
/ metabolism
Ventricular Remodeling
Virus Attachment
Virus Internalization
/ drug effects
COVID-19
angiotensin-converting enzyme 2
inflammation
magnetic resonance imaging
thrombosis
Journal
Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103
Informations de publication
Date de publication:
16 04 2021
16 04 2021
Historique:
entrez:
15
4
2021
pubmed:
16
4
2021
medline:
30
4
2021
Statut:
ppublish
Résumé
A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences. This update provides a review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection.
Identifiants
pubmed: 33856918
doi: 10.1161/CIRCRESAHA.121.317997
pmc: PMC8048382
doi:
Substances chimiques
Biomarkers
0
NRP1 protein, human
0
RNA, Messenger
0
Spike Glycoprotein, Coronavirus
0
Troponin
0
spike protein, SARS-CoV-2
0
Neuropilin-1
144713-63-3
Angiotensin-Converting Enzyme 2
EC 3.4.17.23
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1214-1236Subventions
Organisme : NHGRI NIH HHS
ID : U01 HG007690
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA260513
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL155107
Pays : United States
Organisme : NHLBI NIH HHS
ID : K01 HL140187
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL128856
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA232097
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111314
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL053596
Pays : United States
Organisme : NHLBI NIH HHS
ID : U54 HL119145
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL155096
Pays : United States
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