An intercrypt subpopulation of goblet cells is essential for colonic mucus barrier function.
Animals
Cell Differentiation
Colitis
/ chemically induced
Colitis, Ulcerative
/ pathology
Colon
/ cytology
Goblet Cells
/ cytology
Humans
Intestinal Mucosa
/ cytology
Intestine, Small
/ cytology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Mucus
/ physiology
Proto-Oncogene Proteins c-ets
/ genetics
Transcriptome
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
16 04 2021
16 04 2021
Historique:
received:
09
03
2020
accepted:
05
03
2021
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
1
5
2021
Statut:
ppublish
Résumé
The intestinal mucus layer, an important element of epithelial protection, is produced by goblet cells. Intestinal goblet cells are assumed to be a homogeneous cell type. In this study, however, we delineated their specific gene and protein expression profiles and identified several distinct goblet cell populations that form two differentiation trajectories. One distinct subtype, the intercrypt goblet cells (icGCs), located at the colonic luminal surface, produced mucus with properties that differed from the mucus secreted by crypt-residing goblet cells. Mice with defective icGCs had increased sensitivity to chemically induced colitis and manifested spontaneous colitis with age. Furthermore, alterations in mucus and reduced numbers of icGCs were observed in patients with both active and remissive ulcerative colitis, which highlights the importance of icGCs in maintaining functional protection of the epithelium.
Identifiants
pubmed: 33859001
pii: 372/6539/eabb1590
doi: 10.1126/science.abb1590
pmc: PMC8542866
mid: NIHMS1738550
pii:
doi:
Substances chimiques
Proto-Oncogene Proteins c-ets
0
Spdef protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : 694181
Pays : International
Organisme : NIAID NIH HHS
ID : R37 AI032738
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI095473
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI125956
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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