Serotonin 2 Receptors, Agomelatine, and Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease.
Journal
Behavioural neurology
ISSN: 1875-8584
Titre abrégé: Behav Neurol
Pays: Netherlands
ID NLM: 8914585
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
01
2021
revised:
16
03
2021
accepted:
24
03
2021
entrez:
16
4
2021
pubmed:
17
4
2021
medline:
19
8
2021
Statut:
epublish
Résumé
There are nearly 50 million Alzheimer's disease (AD) patients worldwide, 90% of whom develop behavioral and psychological symptoms of dementia (BPSD), which increase the mortality rate of patients, and impose an economic and care burden on families and society. As a neurotransmitter and neuromodulator, serotonin is involved in the regulation of psychoemotional, sleep, and feeding functions. Accumulating data support the importance of serotonin in the occurrence and development of BPSD. Studies have shown that reduction of serotonin receptors can increase depression and mental symptoms in AD patients. At present, there is no drug treatment for AD approved by the US Food and Drug Administration. Among them, agomelatine, as a new type of antidepressant, can act on serotonin 2 receptors to improve symptoms such as depression and anxiety. At present, research on BPSD is still in the preliminary exploratory stage, and there are still a lot of unknowns. This review summarizes the relationship between serotonin 2 receptors, agomelatine, and BPSD. It provides a new idea for the study of the pathogenesis and treatment of BPSD.
Identifiants
pubmed: 33859767
doi: 10.1155/2021/5533827
pmc: PMC8026319
doi:
Substances chimiques
Acetamides
0
Receptors, Serotonin, 5-HT2
0
agomelatine
137R1N49AD
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
5533827Informations de copyright
Copyright © 2021 Hui-Hua Li et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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