Bifurcation analyses and potential landscapes of a cortex-basal ganglia-thalamus model.
Journal
IET systems biology
ISSN: 1751-8857
Titre abrégé: IET Syst Biol
Pays: England
ID NLM: 101301198
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
06
03
2021
received:
28
10
2020
accepted:
18
03
2021
pubmed:
17
4
2021
medline:
15
12
2021
entrez:
16
4
2021
Statut:
ppublish
Résumé
The dynamics of cortical neuronal activity plays important roles in controlling body movement and is regulated by connection weights between neurons in a cortex-basal ganglia-thalamus (BGCT) loop. Beta-band oscillation of cortical activity is closely associated with the movement disorder of Parkinson's disease, which is caused by an imbalance in the connection weights of direct and indirect pathways in the BGCT loop. In this study, the authors investigate how the dynamics of cortical activity are modulated by connection weights of direct and indirect pathways in the BGCT loop under low dopamine levels through bifurcation analyses and potential landscapes. The results reveal that cortical activity displays rich dynamics under different connection weights, including one, two, or three stable steady states, one or two stable limit cycles, and the coexistence of one stable limit cycle with one stable steady state or two stable ones. For a low dopamine level, cortical activity exhibits oscillation for larger connection weights of direct and indirect pathways. The stability of these stable dynamics is explored by the potential landscapes.
Identifiants
pubmed: 33861900
doi: 10.1049/syb2.12018
pmc: PMC8675854
doi:
Substances chimiques
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-109Informations de copyright
© 2021 The Authors. IET Systems Biology published by John Wiley & Sons Ltd on behalf of The Institution of Engineering and Technology.
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