Maturing secretory granules: Where secretory and endocytic pathways converge.

Animals Biological Transport Cell Membrane / metabolism Endocytosis / physiology Endoplasmic Reticulum / metabolism Eukaryotic Cells / metabolism Exocytosis / physiology Humans Lysosomes / metabolism Organelle Biogenesis Secretory Vesicles / metabolism Signal Transduction trans-Golgi Network / metabolism
Endocytic trafficking Organelle biogenesis Post-Golgi trafficking Regulated secretion Secretory granule

Journal

Advances in biological regulation
ISSN: 2212-4934
Titre abrégé: Adv Biol Regul
Pays: England
ID NLM: 101572336

Informations de publication

Date de publication:
05 2021
Historique:
received: 18 02 2021
revised: 10 03 2021
accepted: 18 03 2021
pubmed: 19 4 2021
medline: 30 12 2021
entrez: 18 4 2021
Statut: ppublish

Résumé

Secretory granules (SGs) are specialized organelles responsible for the storage and regulated release of various biologically active molecules from the endocrine and exocrine systems. Thus, proper SG biogenesis is critical to normal animal physiology. Biogenesis of SGs starts at the trans-Golgi network (TGN), where immature SGs (iSGs) bud off and undergo maturation before fusing with the plasma membrane (PM). How iSGs mature is unclear, but emerging studies have suggested an important role for the endocytic pathway. The requirement for endocytic machinery in SG maturation blurs the line between SGs and another class of secretory organelles called lysosome-related organelles (LROs). Therefore, it is important to re-evaluate the differences and similarities between SGs and LROs.

Identifiants

DOI: 10.1016/j.jbior.2021.100807 PMID: 33866198
pubmed: 33866198
pii: S2212-4926(21)00023-3
doi: 10.1016/j.jbior.2021.100807
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100807

Subventions

Organisme : CIHR
ID : PJT-162165
Pays : Canada
Organisme : CIHR
ID : MOP-119483
Pays : Canada
Organisme : CIHR
ID : IG1-115714
Pays : Canada

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Cheng-I Jonathan Ma (CJ)

Cell Biology Program, The Hospital for Sick Children, PGCRL Building, Room 15.9716, 686 Bay Street, Toronto, Ontario, M5G 0A4, Canada; Institute of Medical Science, University of Toronto, Medical Sciences Building, Room 2374, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada.

Jason Burgess (J)

Cell Biology Program, The Hospital for Sick Children, PGCRL Building, Room 15.9716, 686 Bay Street, Toronto, Ontario, M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Room 4396, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada.

Julie A Brill (JA)

Cell Biology Program, The Hospital for Sick Children, PGCRL Building, Room 15.9716, 686 Bay Street, Toronto, Ontario, M5G 0A4, Canada; Institute of Medical Science, University of Toronto, Medical Sciences Building, Room 2374, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Medical Sciences Building, Room 4396, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada. Electronic address: julie.brill@sickkids.ca.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Métabolisme › Transport biologique › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Endocytose › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Réticulum endoplasmique › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Cellules › Cellules eucaryotes › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Exocytose › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Phénomènes biologiques › Biogenèse des organelles › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Vésicules de transport › Vésicules de sécrétion › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Maturing secretory granules: Where secretory...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Appareil de Golgi › Réseau trans-golgien › Maturing secretory granules: Where secretory...