Adiponectin involved in portal flow hepatic extraction of 13C-methacetin in obesity and non-alcoholic fatty liver.

Acetamides Adiponectin Adult Carbon Isotopes Humans Liver / diagnostic imaging Non-alcoholic Fatty Liver Disease / diagnostic imaging Obesity / complications
Adiponectin Breath test Leptin Liver function Liver steatosis Metabolic syndrome Stable isotopes

Journal

European journal of internal medicine
ISSN: 1879-0828
Titre abrégé: Eur J Intern Med
Pays: Netherlands
ID NLM: 9003220

Informations de publication

Date de publication:
07 2021
Historique:
received: 09 12 2020
revised: 23 02 2021
accepted: 25 03 2021
pubmed: 20 4 2021
medline: 24 7 2021
entrez: 19 4 2021
Statut: ppublish

Résumé

Obesity and non-alcoholic fatty liver disease (NAFLD) are high prevalence, inter-related conditions at increased risk for advanced liver diseases and related mortality. Adiponectin and leptin have divergent roles in the pathogenesis of fat accumulation and NAFLD. However, the relationships between body and liver fat accumulation, early modification of liver function and unbalanced adipokine levels are still scarcely explored. We studied by (13C)-methacetin breath test ((13C)-MBT) 67 adults stratified according to body mass index, and to presence/absence of ultrasonographic nonalcoholic fatty liver disease (uNAFLD). uNAFLD was detected in 20%, 73% and 96% of normal weight, overweight and obese subjects, respectively. The delta over baseline after 15 min (DOB

Identifiants

DOI: 10.1016/j.ejim.2021.03.036 PMID: 33867228
pubmed: 33867228
pii: S0953-6205(21)00108-4
doi: 10.1016/j.ejim.2021.03.036
pii:
doi:

Substances chimiques

Acetamides 0
Adiponectin 0
Carbon Isotopes 0
methacetin 13E468TFHP
Carbon-13 FDJ0A8596D

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

56-64

Commentaires et corrections

Type : ErratumIn
Type : CommentIn

Informations de copyright

Copyright © 2021 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Auteurs

Agostino Di Ciaula (A)

Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari 70124, Italy. Electronic address: agostinodiciaula@tiscali.it.

Federico Carbone (F)

First Clinic of internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa - Italian Cardiovascular Network, 10 Largo Benzi, 16132 Genoa, Italy.. Electronic address: ferico.carbone@edu.unige.it.

Harshitha Shanmugham (H)

Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari 70124, Italy.

Emilio Molina-Molina (E)

Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari 70124, Italy.

Leonilde Bonfrate (L)

Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari 70124, Italy. Electronic address: leonilde.bonfrate@uniba.it.

Stefano Ministrini (S)

Internal Medicine, Department of Medicine, Università degli Studi di Perugia, 1 piazzale Gambuli, 06129, Perugia, Italy.

Fabrizio Montecucco (F)

First Clinic of internal Medicine, Department of Internal Medicine, University of Genoa, 6 viale Benedetto XV, 16132 Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa - Italian Cardiovascular Network, 10 Largo Benzi, 16132 Genoa, Italy.. Electronic address: fabrizio.montecucco@unige.itfed.

Piero Portincasa (P)

Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Aldo Moro, Bari 70124, Italy. Electronic address: piero.portincasa@uniba.it.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides acycliques › Acétamides › Adiponectin involved in portal flow hepatic...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Adipokines › Adiponectine › Adiponectin involved in portal flow hepatic...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adiponectin involved in portal flow hepatic...
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Isotopes du carbone › Adiponectin involved in portal flow hepatic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Adiponectin involved in portal flow hepatic...
questionsmedicales.fr › Système digestif › Foie › Adiponectin involved in portal flow hepatic...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Adiponectin involved in portal flow hepatic...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Adiponectin involved in portal flow hepatic...