Role of Polymorphisms of NKG2D Receptor and Its Ligands in Acute Myeloid Leukemia and Human Stem Cell Transplantation.

Disease-Free Survival Donor Selection / methods Hematopoietic Stem Cell Transplantation Histocompatibility Antigens Class I / genetics Humans Killer Cells, Natural / immunology Leukemia, Myeloid, Acute / genetics Ligands NK Cell Lectin-Like Receptor Subfamily K / genetics Neoplasm Recurrence, Local / epidemiology Polymorphism, Single Nucleotide Precision Medicine / methods Treatment Outcome
MICA MICB ULBP acute myeloid leukemia hematopoietic stem cell transplant natural killer group 2 member D polymorphism

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2021
Historique:
received: 10 01 2021
accepted: 15 03 2021
entrez: 19 4 2021
pubmed: 20 4 2021
medline: 25 9 2021
Statut: epublish

Résumé

Natural killer cells possess key regulatory function in various malignant diseases, including acute myeloid leukemia. NK cell activity is driven by signals received through ligands binding activating or inhibitory receptors. Their activity towards elimination of transformed or virally infected cells can be mediated through MICA, MICB and ULBP ligands binding the activating receptor NKG2D. Given the efficiency of NK cells, potential target cells developed multiple protecting mechanisms to overcome NK cells killing on various levels of biogenesis of NKG2D ligands. Targeted cells can degrade ligand transcripts

Identifiants

DOI: 10.3389/fimmu.2021.651751 PMID: 33868289 PMC: PMC8044845
pubmed: 33868289
doi: 10.3389/fimmu.2021.651751
pmc: PMC8044845
doi:

Substances chimiques

Histocompatibility Antigens Class I 0
KLRK1 protein, human 0
Ligands 0
MHC class I-related chain A 0
MICB antigen 0
NK Cell Lectin-Like Receptor Subfamily K 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

651751

Informations de copyright

Copyright © 2021 Machuldova, Holubova, Caputo, Cedikova, Jindra, Houdova and Pitule.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Alena Machuldova (A)

Laboratory of Tumor Biology and Immunotherapy, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.

Monika Holubova (M)

Laboratory of Tumor Biology and Immunotherapy, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

Valentina S Caputo (VS)

Hugh & Josseline Langmuir Center for Myeloma Research, Center for Hematology, Department of Immunology and Inflammation, Imperial College London, London, United Kingdom.
Cancer Biology and Therapy Laboratory, School of Applied Sciences, London South Bank University, London, United Kingdom.

Miroslava Cedikova (M)

Laboratory of Tumor Biology and Immunotherapy, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.

Pavel Jindra (P)

Department of Haematology and Oncology, University Hospital Pilsen, Pilsen, Czechia.

Lucie Houdova (L)

NTIS, Faculty of Applied Sciences, University of West Bohemia, Pilsen, Czechia.

Pavel Pitule (P)

Laboratory of Tumor Biology and Immunotherapy, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.
Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czechia.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Survie sans rechute › Role of Polymorphisms of NKG2D Receptor and...
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questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs de cellules tueuses naturelles › Récepteurs de cellules NK de type lectine › Sous-famille K des récepteurs de cellules NK de type lectine › Role of Polymorphisms of NKG2D Receptor and...
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