Multiscale analysis of single and double maternal-zygotic
Animals
Blastocyst
/ metabolism
Cell Cycle
Cell Differentiation
Cell Division
Cytokinesis
Databases, Genetic
Embryo Culture Techniques
Female
Gene Expression Regulation, Developmental
Humans
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Video
Morphogenesis
Mutation
Myosin Heavy Chains
/ genetics
Nonmuscle Myosin Type IIB
/ genetics
Time Factors
Time-Lapse Imaging
actomyosin contractility
developmental biology
lumen
mammalian development
mouse
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
19 04 2021
19 04 2021
Historique:
received:
18
03
2021
accepted:
28
03
2021
pubmed:
20
4
2021
medline:
27
10
2021
entrez:
19
4
2021
Statut:
epublish
Résumé
During the first days of mammalian development, the embryo forms the blastocyst, the structure responsible for implanting the mammalian embryo. Consisting of an epithelium enveloping the pluripotent inner cell mass and a fluid-filled lumen, the blastocyst results from a series of cleavage divisions, morphogenetic movements, and lineage specification. Recent studies have identified the essential role of actomyosin contractility in driving cytokinesis, morphogenesis, and fate specification, leading to the formation of the blastocyst. However, the preimplantation development of contractility mutants has not been characterized. Here, we generated single and double maternal-zygotic mutants of non-muscle myosin II heavy chains (NMHCs) to characterize them with multiscale imaging. We found that
Identifiants
pubmed: 33871354
doi: 10.7554/eLife.68536
pii: 68536
pmc: PMC8096435
doi:
pii:
Substances chimiques
Myh9 protein, mouse
0
Nonmuscle Myosin Type IIB
EC 3.6.1.-
nonmuscle myosin type IIB heavy chain
EC 3.6.1.-
Myosin Heavy Chains
EC 3.6.4.1
Banques de données
GEO
['GSE45719', 'GSE36552']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Video-Audio Media
Langues
eng
Sous-ensembles de citation
IM
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2021, Schliffka et al.
Déclaration de conflit d'intérêts
MS is employed by Carl Zeiss SAS via a public PhD programme Conventions Industrielles de Formation par la Recherche (CIFRE) co-funded by the Association Nationale de la Recherche et de la Technologie (ANRT). AT, ÖÖ, Ld, OP, DP, JM No competing interests declared
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