Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
13 05 2021
13 05 2021
Historique:
pubmed:
21
4
2021
medline:
16
6
2021
entrez:
20
4
2021
Statut:
ppublish
Résumé
Dihydroorotate dehydrogenase (DHODH) has been clinically validated as a target for the development of new antimalarials. Experience with clinical candidate triazolopyrimidine DSM265 (
Identifiants
pubmed: 33876936
doi: 10.1021/acs.jmedchem.1c00173
pmc: PMC8171248
mid: NIHMS1702324
doi:
Substances chimiques
Antimalarials
0
Dihydroorotate Dehydrogenase
0
Enzyme Inhibitors
0
Pyrroles
0
Oxidoreductases Acting on CH-CH Group Donors
EC 1.3.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
6085-6136Subventions
Organisme : NIAID NIH HHS
ID : R01 AI103947
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI109023
Pays : United States
Organisme : NIH HHS
ID : S10 OD025018
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI089688
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI139179
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES007020
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI093380
Pays : United States
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