Perinatal determinants of neonatal hair glucocorticoid concentrations.
Chorioamnionitis
Cortisol
Hypothalamus–pituitary–adrenal axis
Parturition
Preterm birth
Stress
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
07
12
2020
revised:
21
02
2021
accepted:
05
04
2021
pubmed:
21
4
2021
medline:
11
3
2022
entrez:
20
4
2021
Statut:
ppublish
Résumé
Adult hair glucocorticoid concentrations reflect months of hypothalamic-pituitary-adrenal axis activity. However, little is known about the determinants of neonatal hair glucocorticoids. We tested associations between perinatal exposures and neonatal hair glucocorticoids. Cortisol and cortisone were measured by LC-MS/MS in paired maternal and infant hair samples collected within 10 days of birth (n = 49 term, n = 47 preterm), with neonatal samples collected at 6-weeks in n = 54 preterm infants. We demonstrate cortisol accumulation in hair increases with fetal maturity, with hair cortisol being higher in term than preterm born infants after delivery (median 401 vs 106 pg/mg; p < 0.001). In term born infants, neonatal hair cortisol is positively associated with maternal hair cortisol concentration (β = 0.240, p = 0.045) and negatively associated with birthweight z-score (β = -0.340, p = 0.006). Additionally, being born without maternal labour is associated with lower hair cortisol concentrations (β = -0.489, p < 0.001) and a lower ratio of cortisol to cortisone (β = -0.484, p = 0.001). In preterm infants, histological chorioamnionitis is associated with a higher cortisol to cortisone ratio in hair (β = 0.459, p = 0.001). In samples collected 6 weeks after preterm birth, hair cortisol concentration is associated with cortisol hair concentrations measured after birth (β = 0.523, p < 0.001), chorioamnionitis (β = 0.250, p = 0.049) and postnatal exposures including intravenous hydrocortisone therapy (β = 0.343, p < 0.007) and neonatal sepsis (β = 0.290, p = 0.017). In summary, neonatal hair cortisol is associated with birth gestation, maternal hair cortisol concentration and fetal growth. Additionally, exposures at delivery are important determinants of hair cortisol, and should be considered in the design of future research investigating how neonatal hair cortisol relates to prenatal exposures or fetal development.
Identifiants
pubmed: 33878601
pii: S0306-4530(21)00097-4
doi: 10.1016/j.psyneuen.2021.105223
pmc: PMC8155393
pii:
doi:
Substances chimiques
Glucocorticoids
0
Cortisone
V27W9254FZ
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105223Subventions
Organisme : Medical Research Council
ID : MRC G1002033
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/18/5/34216
Pays : United Kingdom
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
Références
Dev Psychobiol. 2017 Jan;59(1):123-127
pubmed: 27255609
Physiol Behav. 2011 Aug 3;104(2):348-53
pubmed: 21397617
Clin Perinatol. 2009 Mar;36(1):177-88
pubmed: 19161874
Front Physiol. 2020 May 25;11:462
pubmed: 32523541
Horm Res Paediatr. 2016;85(4):221-31
pubmed: 26943327
Sci Rep. 2016 Dec 01;6:37932
pubmed: 27905410
Sci Rep. 2019 Aug 19;9(1):11997
pubmed: 31427664
Psychoneuroendocrinology. 2016 Apr;66:111-7
pubmed: 26802598
Nature. 1977 Mar 10;266(5598):179-81
pubmed: 859592
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jun 1;928:1-8
pubmed: 23584040
Ultraschall Med. 2012 Dec;33(7):E75-E79
pubmed: 22623130
Nat Rev Endocrinol. 2014 Jul;10(7):391-402
pubmed: 24863382
Pediatr Res. 2014 May;75(5):584-7
pubmed: 24500615
Lancet. 2016 Apr 30;387(10030):1827-36
pubmed: 26916176
Arch Dis Child Fetal Neonatal Ed. 2004 Mar;89(2):F96-100
pubmed: 14977889
Placenta. 2014 May;35(5):291-6
pubmed: 24680291
Psychoneuroendocrinology. 2013 Jun;38(6):907-15
pubmed: 23046825
Sci Rep. 2017 Aug 31;7(1):10263
pubmed: 28860525
Dev Psychobiol. 2021 Apr;63(3):409-436
pubmed: 32783213
Neonatology. 2007;92(1):42-9
pubmed: 17356304
Endocr Rev. 2018 Jun 1;39(3):241-260
pubmed: 29385440
Pediatr Res. 2014 Apr;75(4):476-81
pubmed: 24418932
J Clin Endocrinol Metab. 1980 Mar;50(3):431-6
pubmed: 7358829
Physiol Rev. 2013 Jul;93(3):1139-206
pubmed: 23899562
Am J Obstet Gynecol. 2012 Dec;207(6):446-54
pubmed: 22840973
Psychoneuroendocrinology. 2016 Sep;71:12-8
pubmed: 27235635
Obstet Gynecol. 2000 Aug;96(2):287-90
pubmed: 10908779
Psychoneuroendocrinology. 2019 Nov;109:104381
pubmed: 31442935
Pediatr Res. 2005 Dec;58(6):1233-7
pubmed: 16306199
Brain Behav Immun. 2020 Nov;90:311-318
pubmed: 32920182
Proc Nutr Soc. 1998 Feb;57(1):113-22
pubmed: 9571716
Neurosci Biobehav Rev. 2015 Jun;53:1-24
pubmed: 25795521
Arch Dis Child. 2017 Jan;102(1):97-102
pubmed: 27512082
Lancet. 1998 Aug 29;352(9129):707-8
pubmed: 9728994
Clin J Pain. 2010 Oct;26(8):698-704
pubmed: 20664338
Int J Environ Res Public Health. 2016 Mar 18;13(3):
pubmed: 26999185
J Pregnancy. 2013;2013:412831
pubmed: 23533760
Am J Obstet Gynecol. 2000 Sep;183(3):669-73
pubmed: 10992191
PLoS One. 2018 Jul 6;13(7):e0200279
pubmed: 29979751
Am J Primatol. 2017 Feb;79(2):1-9
pubmed: 27643479
Endocr Connect. 2017 Nov;6(8):692-699
pubmed: 28954736
Eur J Endocrinol. 2009 Sep;161(3):419-25
pubmed: 19542242
Elife. 2020 Nov 24;9:
pubmed: 33228850
Lancet. 2014 Sep 6;384(9946):857-68
pubmed: 25209487
Pediatrics. 2013 Apr;131(4):e1240-63
pubmed: 23509172
Psychoneuroendocrinology. 2017 Sep;83:172-181
pubmed: 28641158
BMC Psychiatry. 2017 Jun 6;17(1):213
pubmed: 28587668
Neuroendocrinology. 2013;98(2):106-15
pubmed: 23969897
Endocr Rev. 2009 Dec;30(7):753-89
pubmed: 19837868
Nat Rev Endocrinol. 2014 Jul;10(7):403-11
pubmed: 24863383
Nutr Rev. 2017 Dec 1;75(12):951-970
pubmed: 29186623
Psychoneuroendocrinology. 2013 Jan;38(1):1-11
pubmed: 22998948
J Matern Fetal Neonatal Med. 2004 Jul;16(1):33-6
pubmed: 15370080
Endocr Rev. 2013 Dec;34(6):885-916
pubmed: 23970762
Horm Res Paediatr. 2018;90(5):299-307
pubmed: 30541006
Pediatrics. 2004 Dec;114(6):1649-57
pubmed: 15574629
Pediatrics. 1997 Feb;99(2):E6
pubmed: 9099763
Psychoneuroendocrinology. 2017 Mar;77:261-274
pubmed: 28135674