Oxytocin and social anxiety: Interactions with sex hormones.

Anxiety Disorders / physiopathology Female Gonadal Steroid Hormones / metabolism Humans Male Oxytocin / metabolism
Estradiol Hormonal contraception Hormonal interaction Oxytocin Social anxiety Testosterone

Journal

Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148

Informations de publication

Date de publication:
06 2021
Historique:
received: 29 05 2020
revised: 01 03 2021
accepted: 06 04 2021
pubmed: 21 4 2021
medline: 11 3 2022
entrez: 20 4 2021
Statut: ppublish

Résumé

Oxytocin has been associated with anxiolytic and stress reducing effects in a number of studies. Less is known about the associations of endogenous oxytocin concentrations and their interaction with other hormones such as sex hormones in relation to self-reported anxiety levels. In this study, endogenous oxytocin and sex hormone levels were analyzed in 99 high (51 women) and 100 low (50 women) socially anxious individuals. Regression analyses showed that women with high oxytocin and estradiol levels reported a lower total Liebowitz Social Anxiety Score (LSAS) as well as a lower score on the subscale LSAS Fear. This association of hormonal interaction with social anxiety scores was significant in the subsample of high socially anxious women. In men there were no significant associations for endogenous hormones with LSAS scores. These findings suggest that in women the link between oxytocin and anxiety might be dependent on basal anxiety levels as well as on individual sex hormone levels.

Identifiants

DOI: 10.1016/j.psyneuen.2021.105224 PMID: 33878602
pubmed: 33878602
pii: S0306-4530(21)00098-6
doi: 10.1016/j.psyneuen.2021.105224
pii:
doi:

Substances chimiques

Gonadal Steroid Hormones 0
Oxytocin 50-56-6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105224

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

E Schneider (E)

Institute of Medical Psychology, Center for Psychosocial Medicine, Heidelberg University Hospital, Heidelberg, Germany; Ruprecht-Karls University Heidelberg, Germany. Electronic address: ekaterina.schneider@med.uni-heidelberg.de.

L E Müller (LE)

Clinic of Psychosomatic and Psychotherapy, Hospital Darmstadt, Germany; Department of General Psychiatry, Center for Psychosocial Medicine, Heidelberg University Hospital, Heidelberg, Germany.

B Ditzen (B)

Institute of Medical Psychology, Center for Psychosocial Medicine, Heidelberg University Hospital, Heidelberg, Germany; Ruprecht-Karls University Heidelberg, Germany.

S C Herpertz (SC)

Department of General Psychiatry, Center for Psychosocial Medicine, Heidelberg University Hospital, Heidelberg, Germany.

K Bertsch (K)

Department of General Psychiatry, Center for Psychosocial Medicine, Heidelberg University Hospital, Heidelberg, Germany; Department of Psychology, Ludwig-Maximilians-University Munich, Munich, Germany.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles anxieux › Oxytocin and social anxiety: Interactions with...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Oxytocin and social anxiety: Interactions with...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Oxytocin and social anxiety: Interactions with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones post-hypophysaires › Ocytocine › Oxytocin and social anxiety: Interactions with...