N-Acetyl-α-hydroxy-β-oxotryptamine, a racemic natural product isolated from Streptomyces sp. 80H647.
Anti-Infective Agents
/ chemistry
Antineoplastic Agents
/ chemistry
Biological Products
/ chemistry
Cell Line, Tumor
Crystallography, X-Ray
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Stereoisomerism
Streptomyces
/ chemistry
Structure-Activity Relationship
Tryptamines
/ chemistry
Journal
The Journal of antibiotics
ISSN: 1881-1469
Titre abrégé: J Antibiot (Tokyo)
Pays: England
ID NLM: 0151115
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
26
01
2021
accepted:
11
03
2021
revised:
19
02
2021
pubmed:
22
4
2021
medline:
9
10
2021
entrez:
21
4
2021
Statut:
ppublish
Résumé
N-acetyl-α-hydroxy-β-oxotryptamine (1) along with N-acetyl-β-oxotryptamine (2) and pimprinine (3) were isolated from the culture broth of Streptomyces sp. 80H647. Compound 1 was found to be a racemate via X-ray diffraction analysis and the enantiomers were successfully purified by chiral-phase HPLC. The absolute configuration was assigned by comparison of the calculated and experimental ECD spectra. The α-hydroxy moiety of 1 was vital for cytotoxicity against different cancer cell lines.
Identifiants
pubmed: 33879862
doi: 10.1038/s41429-021-00420-7
pii: 10.1038/s41429-021-00420-7
doi:
Substances chimiques
Anti-Infective Agents
0
Antineoplastic Agents
0
Biological Products
0
Tryptamines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
477-479Références
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