Hepatic Steatosis in Patients With Single Ventricle and a Fontan Circulation.
Adolescent
Adult
Child
Echocardiography
Fatty Liver
/ diagnosis
Female
Follow-Up Studies
Fontan Procedure
/ adverse effects
Heart Defects, Congenital
/ diagnosis
Heart Ventricles
/ abnormalities
Humans
Liver
/ pathology
Magnetic Resonance Imaging
Male
Middle Aged
Ohio
/ epidemiology
Postoperative Complications
/ diagnosis
Prevalence
Prognosis
Retrospective Studies
Young Adult
Fontan associated liver disease
Fontan operation
abdominal fat
adult congenital heart disease
hepatic steatosis
nonalcoholic fatty liver disease
obesity
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
04 05 2021
04 05 2021
Historique:
pubmed:
22
4
2021
medline:
26
10
2021
entrez:
21
4
2021
Statut:
ppublish
Résumé
Background Hepatic steatosis, caused by nonalcoholic fatty liver disease, is a leading cause of chronic liver disease. The interplay between hepatic steatosis and the development of liver disease following the Fontan procedure is not well understood. This study examined the prevalence and associations of hepatic steatosis in patients with a Fontan circulation. Methods and Results This was a single-center retrospective study of 95 patients with a Fontan circulation with liver magnetic resonance imaging performed between 2012 and 2019. The average age at magnetic resonance imaging was 21.5±8.5 years. The percent liver fat signal was determined using magnetic resonance chemical shift-encoded proton density fat fraction imaging. Hepatic steatosis was defined as liver fat ≥5% and was present in 10.5% of the cohort. The presence of hepatic steatosis was associated with higher body mass index (29±4 versus 24±6 kg/m
Identifiants
pubmed: 33880928
doi: 10.1161/JAHA.120.019942
pmc: PMC8200742
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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