Prediction of Speech, Swallowing, and Quality of Life in Oral Cavity Cancer Patients: A Pilot Study.
Adult
Aged
Aged, 80 and over
Chemoradiotherapy, Adjuvant
/ adverse effects
Deglutition
/ drug effects
Deglutition Disorders
/ epidemiology
Female
Humans
Male
Middle Aged
Mouth Neoplasms
/ complications
Oral Surgical Procedures
/ adverse effects
Pilot Projects
Prognosis
Prospective Studies
Quality of Life
Retrospective Studies
Risk Assessment
/ methods
Speech
/ drug effects
Speech Disorders
/ epidemiology
Young Adult
Oral cancer
patient reported outcomes
quality of life
reconstruction
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
09
03
2021
received:
21
01
2021
accepted:
09
04
2021
pubmed:
22
4
2021
medline:
25
11
2021
entrez:
21
4
2021
Statut:
ppublish
Résumé
To investigate the impact of specific treatment-related variables on functional and quality of life outcomes in oral cavity cancer (OCC) patients. Retrospective Cohort. Patients with primary OCC at least 6 months after resection and adjuvant therapy were included. Patients completed surveys including the Speech Handicap Index (SHI), M.D. Anderson Dysphagia Inventory (MDADI), and Functional Assessment of Cancer Therapy-Head and Neck (FACT-HN). Performance Status Scale (PSS) and tongue mobility scale were completed to allow provider-rated assessment of speech and tongue mobility, respectively. Additional details regarding treatment were also collected. These data were used to generate a predictive model using linear regression. Fifty-three patients with oral tongue and/or floor of mouth (FOM) resection were included in our study. In multivariable analysis, greater postoperative tongue range of motion (ROM) and time since treatment improved SHI. Flap reconstruction and greater postoperative tongue ROM increased MDADI and PSS (eating and speech). A larger volume of resected tissue was inversely correlated with PSS (diet and speech). Tumor site was an important predictor of PSS (all sections). There were no statistically significant predictors of FACT-HN. In this pilot study, we propose a battery of tools to assess function in OCC patients treated with surgery. Using the battery of tools we propose, our results show that a surgical endpoint that preserves tongue mobility and employs flap reconstruction resulted in better outcomes, whereas those with greater volume of tissue resected and FOM involvement resulted in poorer outcomes. Larger prospective studies are needed to validate our findings. 3 Laryngoscope, 131:2497-2504, 2021.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2497-2504Subventions
Organisme : Massachusetts Eye and Ear
Informations de copyright
© 2021 The American Laryngological, Rhinological and Otological Society, Inc.
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