A genome-wide analysis of cardiac lesions of pigs that die during transport: Is heart failure of in-transit-loss pigs associated with a heritable cardiomyopathy?


Journal

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire
ISSN: 1928-9022
Titre abrégé: Can J Vet Res
Pays: Canada
ID NLM: 8607793

Informations de publication

Date de publication:
Apr 2021
Historique:
received: 03 04 2020
accepted: 25 09 2020
entrez: 22 4 2021
pubmed: 23 4 2021
medline: 21 9 2021
Statut: ppublish

Résumé

While heart failure is a primary cause of death for many in-transit-loss (ITL) pigs, the underlying cause of these deaths is not known. Cardiomyopathies are considered a common cause of heart failure in humans and often have a genetic component. The objective of this study was to determine if genes associated with cardiomyopathies could be identified in ITL pigs. Samples from the hearts of pigs that died during transport to an abattoir in Ontario, Canada were collected and genotyped along with samples from pigs that did not die during transport (ILT hearts: Bien que l’insuffisance cardiaque soit la principale cause de décès chez de nombreux porcs perdus en transit (ITL), la cause sous-jacente de ces décès n’est pas connue. Les cardiomyopathies sont considérées comme une cause fréquente d’insuffisance cardiaque chez l’homme et ont souvent une composante génétique. L’objectif de cette étude était de déterminer si des gènes associés aux cardiomyopathies pouvaient être identifiés chez les porcs ITL. Des échantillons de coeurs de porcs morts pendant le transport vers un abattoir en Ontario, au Canada, ont été prélevés et génotypés avec des échantillons de porcs qui ne sont pas morts pendant le transport (coeurs ILT:

Autres résumés

Type: Publisher (fre)
Bien que l’insuffisance cardiaque soit la principale cause de décès chez de nombreux porcs perdus en transit (ITL), la cause sous-jacente de ces décès n’est pas connue. Les cardiomyopathies sont considérées comme une cause fréquente d’insuffisance cardiaque chez l’homme et ont souvent une composante génétique. L’objectif de cette étude était de déterminer si des gènes associés aux cardiomyopathies pouvaient être identifiés chez les porcs ITL. Des échantillons de coeurs de porcs morts pendant le transport vers un abattoir en Ontario, au Canada, ont été prélevés et génotypés avec des échantillons de porcs qui ne sont pas morts pendant le transport (coeurs ILT:

Identifiants

pubmed: 33883819
pii: cjvr_02_119
pmc: PMC7995549

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

119-126

Informations de copyright

Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.

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Auteurs

Katherine Zurbrigg (K)

Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (Zurbrigg, Friendship, O'Sullivan); Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA (Bertolini, Walugembe, Rothschild); National Institute of Aquatic Resources, Technical University of Denmark, Lyngby, Denmark (Bertolini); Veterinary Pathology Consultant, Ontario (van Dreumel), Veterinary Epidemiology Consultant, Elora, Ontario (Alves).

Francesca Bertolini (F)

Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (Zurbrigg, Friendship, O'Sullivan); Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA (Bertolini, Walugembe, Rothschild); National Institute of Aquatic Resources, Technical University of Denmark, Lyngby, Denmark (Bertolini); Veterinary Pathology Consultant, Ontario (van Dreumel), Veterinary Epidemiology Consultant, Elora, Ontario (Alves).

Muhammed Walugembe (M)

Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (Zurbrigg, Friendship, O'Sullivan); Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA (Bertolini, Walugembe, Rothschild); National Institute of Aquatic Resources, Technical University of Denmark, Lyngby, Denmark (Bertolini); Veterinary Pathology Consultant, Ontario (van Dreumel), Veterinary Epidemiology Consultant, Elora, Ontario (Alves).

Toni van Dreumel (T)

Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (Zurbrigg, Friendship, O'Sullivan); Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA (Bertolini, Walugembe, Rothschild); National Institute of Aquatic Resources, Technical University of Denmark, Lyngby, Denmark (Bertolini); Veterinary Pathology Consultant, Ontario (van Dreumel), Veterinary Epidemiology Consultant, Elora, Ontario (Alves).

David Alves (D)

Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (Zurbrigg, Friendship, O'Sullivan); Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA (Bertolini, Walugembe, Rothschild); National Institute of Aquatic Resources, Technical University of Denmark, Lyngby, Denmark (Bertolini); Veterinary Pathology Consultant, Ontario (van Dreumel), Veterinary Epidemiology Consultant, Elora, Ontario (Alves).

Robert Friendship (R)

Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (Zurbrigg, Friendship, O'Sullivan); Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA (Bertolini, Walugembe, Rothschild); National Institute of Aquatic Resources, Technical University of Denmark, Lyngby, Denmark (Bertolini); Veterinary Pathology Consultant, Ontario (van Dreumel), Veterinary Epidemiology Consultant, Elora, Ontario (Alves).

Terri L O'Sullivan (TL)

Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (Zurbrigg, Friendship, O'Sullivan); Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA (Bertolini, Walugembe, Rothschild); National Institute of Aquatic Resources, Technical University of Denmark, Lyngby, Denmark (Bertolini); Veterinary Pathology Consultant, Ontario (van Dreumel), Veterinary Epidemiology Consultant, Elora, Ontario (Alves).

Max F Rothschild (MF)

Department of Population Medicine, University of Guelph, 50 Stone Road East, Guelph, Ontario N1G 2W1 (Zurbrigg, Friendship, O'Sullivan); Department of Animal Science, Iowa State University, Ames, Iowa 50011, USA (Bertolini, Walugembe, Rothschild); National Institute of Aquatic Resources, Technical University of Denmark, Lyngby, Denmark (Bertolini); Veterinary Pathology Consultant, Ontario (van Dreumel), Veterinary Epidemiology Consultant, Elora, Ontario (Alves).

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