Development of a Pediatric Relative Bioavailability/Bioequivalence Database and Identification of Putative Risk Factors Associated With Evaluation of Pediatric Oral Products.
Administration, Oral
Age Factors
Area Under Curve
Biological Availability
Child
Clinical Trials as Topic
Cross-Over Studies
Databases, Pharmaceutical
/ statistics & numerical data
Drug-Related Side Effects and Adverse Reactions
/ epidemiology
Drugs, Generic
/ administration & dosage
Humans
Models, Biological
Risk Assessment
/ methods
Risk Factors
Therapeutic Equivalency
bioequivalence
oral product
pediatric
relative bioavailability
risk factors
Journal
The AAPS journal
ISSN: 1550-7416
Titre abrégé: AAPS J
Pays: United States
ID NLM: 101223209
Informations de publication
Date de publication:
21 04 2021
21 04 2021
Historique:
received:
06
01
2021
accepted:
06
04
2021
entrez:
22
4
2021
pubmed:
23
4
2021
medline:
30
11
2021
Statut:
epublish
Résumé
Generally, bioequivalence (BE) studies of drug products for pediatric patients are conducted in adults due to ethical reasons. Given the lack of direct BE assessment in pediatric populations, the aim of this work is to develop a database of BE and relative bioavailability (relative BA) studies conducted in pediatric populations and to enable the identification of risk factors associated with certain drug substances or products that may lead to failed BE or different pharmacokinetic (PK) parameters in relative BA studies in pediatrics. A literature search from 1965 to 2020 was conducted in PubMed, Cochrane Library, and Google Scholar to identify BE studies conducted in pediatric populations and relative BA studies conducted in pediatric populations. Overall, 79 studies covering 37 active pharmaceutical ingredients (APIs) were included in the database: 4 bioequivalence studies with data that passed BE evaluations; 2 studies showed bioinequivalence results; 34 relative BA studies showing comparable PK parameters, and 39 relative BA studies showing differences in PK parameters between test and reference products. Based on the above studies, common putative risk factors associated with differences in relative bioavailability (DRBA) in pediatric populations include age-related absorption effects, high inter-individual variability, and poor study design. A database containing 79 clinical studies on BE or relative BA in pediatrics has been developed. Putative risk factors associated with DRBA in pediatric populations are summarized.
Identifiants
pubmed: 33884497
doi: 10.1208/s12248-021-00592-y
pii: 10.1208/s12248-021-00592-y
pmc: PMC8060189
doi:
Substances chimiques
Drugs, Generic
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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