Persistent brainwave disruption and cognitive impairment induced by acute sarin surrogate sub-lethal dose exposure.

Animals Brain Waves / drug effects Chemical Warfare Agents / toxicity Cholinesterase Inhibitors / administration & dosage Cholinesterases / metabolism Cognitive Dysfunction / chemically induced Electrocorticography / drug effects Male Mice Sarin / administration & dosage
4-Nitrophenyl isopropyl methylphosphonate Brain waves Nerve agent Neuroinflammation Sarin surrogate Sublethal exposure

Journal

Toxicology
ISSN: 1879-3185
Titre abrégé: Toxicology
Pays: Ireland
ID NLM: 0361055

Informations de publication

Date de publication:
30 05 2021
Historique:
received: 09 02 2021
revised: 11 04 2021
accepted: 15 04 2021
pubmed: 23 4 2021
medline: 23 6 2021
entrez: 22 4 2021
Statut: ppublish

Résumé

Warfare neurotoxicants such as sarin, soman or VX, are organophosphorus compounds which irreversibly inhibit cholinesterase. High-dose exposure with nerve agents (NA) is known to produce seizure activity and related brain damage, while less is known about the effects of acute sub-lethal dose exposure. The aim of this study was to characterize behavioral, brain activity and neuroinflammatory modifications at different time points after exposure to 4-nitrophenyl isopropyl methylphosphonate (NIMP), a sarin surrogate. In order to decipher the impacts of sub-lethal exposure, we chose 4 different doses of NIMP each corresponding to a fraction of the median lethal dose (LD

Identifiants

DOI: 10.1016/j.tox.2021.152787 PMID: 33887375
pubmed: 33887375
pii: S0300-483X(21)00110-4
doi: 10.1016/j.tox.2021.152787
pii:
doi:

Substances chimiques

Chemical Warfare Agents 0
Cholinesterase Inhibitors 0
Sarin B4XG72QGFM
Cholinesterases EC 3.1.1.8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

152787

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Loïc Angrand (L)

Departement of Toxicology and Chemical Risks, French Armed Forces Biomedical Research Institute, Bretigny sur Orge, France; EnvA, IMRB, Maisons-Alfort, France; Université Paris-Est Créteil, INSERM, Team Relaix, Créteil, France.

Samir Takillah (S)

Departement of Neuroscience, Unit of Fatigue and Vigilance, French Armed Forces Biomedical Research Institute, Bretigny sur Orge, France; VIFASOM Team (EA 7330), Paris Descartes University, Sorbonne Paris Cité, Hôtel Dieu, Paris, France.

Isabelle Malissin (I)

Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Federation of Toxicology APHP, Paris-Diderot University, INSERM UMRS-1144, Paris, France.

Asma Berriche (A)

Departement of Toxicology and Chemical Risks, French Armed Forces Biomedical Research Institute, Bretigny sur Orge, France; CEA, Fontenay aux roses, France.

Chloe Cervera (C)

Departement of Toxicology and Chemical Risks, French Armed Forces Biomedical Research Institute, Bretigny sur Orge, France.

Rosalie Bel (R)

Departement of Toxicology and Chemical Risks, French Armed Forces Biomedical Research Institute, Bretigny sur Orge, France.

Quentin Gerard (Q)

Departement of Toxicology and Chemical Risks, French Armed Forces Biomedical Research Institute, Bretigny sur Orge, France; Normandie University, UNICAEN, INSERM, GIP Cyceron, Institut Blood and Brain @Caen-Normandie (BB@C), UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Caen, France.

Julie Knoertzer (J)

Departement of Toxicology and Chemical Risks, French Armed Forces Biomedical Research Institute, Bretigny sur Orge, France.

Rachid Baati (R)

ICPEES UMR CNRS 7515, Institut de Chimie des Procédés, pour l'Energie, l'Environnement, et la Santé, Strasbourg, France.

Joseph P Kononchik (JP)

Departement of Toxicology and Chemical Risks, French Armed Forces Biomedical Research Institute, Bretigny sur Orge, France.

Bruno Megarbane (B)

VIFASOM Team (EA 7330), Paris Descartes University, Sorbonne Paris Cité, Hôtel Dieu, Paris, France; Department of Medical and Toxicological Critical Care, Lariboisière Hospital, Federation of Toxicology APHP, Paris-Diderot University, INSERM UMRS-1144, Paris, France.

Karine Thibault (K)

Departement of Toxicology and Chemical Risks, French Armed Forces Biomedical Research Institute, Bretigny sur Orge, France. Electronic address: karine.thibault@def.gouv.fr.

Gregory Dal Bo (G)

Departement of Toxicology and Chemical Risks, French Armed Forces Biomedical Research Institute, Bretigny sur Orge, France. Electronic address: greg.dal-bo@chemdef.fr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Persistent brainwave disruption and cognitive...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Ondes du cerveau › Persistent brainwave disruption and cognitive...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Armes › Armes de destruction massive › Armes chimiques › Persistent brainwave disruption and cognitive...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Persistent brainwave disruption and cognitive...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Persistent brainwave disruption and cognitive...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Persistent brainwave disruption and cognitive...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électrocorticographie › Persistent brainwave disruption and cognitive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Persistent brainwave disruption and cognitive...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Phosphonofluoridates › Sarin › Persistent brainwave disruption and cognitive...