Quassinoids: Phytochemistry and antitumor prospect.

Plant Extracts Plants Quassins / pharmacology Simaroubaceae Structure-Activity Relationship
Antitumor activity Chemical source Diverse structures Quassinoids Structure-activity relationships

Journal

Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434

Informations de publication

Date de publication:
Jul 2021
Historique:
received: 28 01 2021
revised: 26 03 2021
accepted: 04 04 2021
pubmed: 23 4 2021
medline: 26 5 2021
entrez: 22 4 2021
Statut: ppublish

Résumé

Quassinoids, originating from the oxidative degradation of tetracyclic tirucallane triterpene, are a diverse class of secondary metabolites identifying from nature mostly in Simaroubaceae family. The crucial pharmacological activities and structural complexity of quassinoids have long fascinated scientists due to their medicinal uses, infamous toxicity, and unique biosynthesis. In the past few decades, 482 quassinoids, assigned to 6 skeletons, have been isolated and identified from plants. The names, classes, molecular formula, and plant sources of these secondary metabolites are collated here. This review will be a detailed update of the naturally occurring quassinoids reported from the plant kingdom, providing an in-depth discussion of their diversity, antitumor activities, structure-activity relationship.

Identifiants

DOI: 10.1016/j.phytochem.2021.112769 PMID: 33887559
pubmed: 33887559
pii: S0031-9422(21)00118-7
doi: 10.1016/j.phytochem.2021.112769
pii:
doi:

Substances chimiques

Plant Extracts 0
Quassins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

112769

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Zhi-Kang Duan (ZK)

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

Zhao-Jun Zhang (ZJ)

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

Shu-Hui Dong (SH)

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

Yu-Xi Wang (YX)

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

Shao-Jiang Song (SJ)

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.

Xiao-Xiao Huang (XX)

Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, Liaoning Province, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address: xiaoxiao270@163.com.

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Classifications MeSH

questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Quassinoids: Phytochemistry and antitumor prospect.
questionsmedicales.fr › Eucaryotes › Plantes › Quassinoids: Phytochemistry and antitumor prospect.
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Quassinoïdes › Quassinoids: Phytochemistry and antitumor prospect.
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Simaroubaceae › Quassinoids: Phytochemistry and antitumor prospect.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Quassinoids: Phytochemistry and antitumor prospect.