Clinical factors associated with death in 3044 COVID-19 patients managed in internal medicine wards in Italy: results from the SIMI-COVID-19 study of the Italian Society of Internal Medicine (SIMI).
Comorbidity
Internal medicine
Mortality from COVID-19
Polypharmacy
SARS-CoV-2
Journal
Internal and emergency medicine
ISSN: 1970-9366
Titre abrégé: Intern Emerg Med
Pays: Italy
ID NLM: 101263418
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
19
02
2021
accepted:
09
04
2021
pubmed:
25
4
2021
medline:
17
7
2021
entrez:
24
4
2021
Statut:
ppublish
Résumé
During the COVID-19 2020 outbreak, a large body of data has been provided on general management and outcomes of hospitalized COVID-19 patients. Yet, relatively little is known on characteristics and outcome of patients managed in Internal Medicine Units (IMU). To address this gap, the Italian Society of Internal Medicine has conducted a nationwide cohort multicentre study on death outcome in adult COVID-19 patients admitted and managed in IMU. This study assessed 3044 COVID-19 patients at 41 referral hospitals across Italy from February 3rd to May 8th 2020. Demographics, comorbidities, organ dysfunction, treatment, and outcomes including death were assessed. During the study period, 697 patients (22.9%) were transferred to intensive care units, and 351 died in IMU (death rate 14.9%). At admission, factors independently associated with in-hospital mortality were age (OR 2.46, p = 0.000), productive cough (OR 2.04, p = 0.000), pre-existing chronic heart failure (OR 1.58, p = 0.017) and chronic obstructive pulmonary disease (OR 1.17, p = 0.048), the number of comorbidities (OR 1.34, p = 0.000) and polypharmacy (OR 1.20, p = 0.000). Of note, up to 40% of elderly patients did not report fever at admission. Decreasing PaO
Identifiants
pubmed: 33893976
doi: 10.1007/s11739-021-02742-8
pii: 10.1007/s11739-021-02742-8
pmc: PMC8065333
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1005-1015Investigateurs
Elisabetta Tombolini
(E)
Thomas Teatini
(T)
Ernesto Crisafulli
(E)
Pier Paolo Sainaghi
(PP)
Lorenzo Zileri Dal Verme
(L)
Salvatore Piano
(S)
Rebecca De Lorenzo
(R)
Gaetano Arcidiacono
(G)
Marco Podda
(M)
Luca Muratori
(L)
Claudia Gabiati
(C)
Francesco Salinaro
(F)
Michelangelo Luciani
(M)
Cecilia Barnini
(C)
Stefania Morra di Cella
(S)
Andrea Dalbeni
(A)
Simonetta Friso
(S)
Michelangelo Luciani
(M)
Filippo Mearelli
(F)
Paolo Malerba
(P)
Francesco Cavallone
(F)
Damiano D'Ardes
(D)
Serena Notargiacomo
(S)
Alfredo De Giorgi
(A)
Marta Mansi
(M)
Elena Buzzetti
(E)
Andrea Ricci
(A)
Francesca Martelli
(F)
Commentaires et corrections
Type : CommentIn
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