Low Threshold for Cutaneous Allergen Sensitization but No Spontaneous Dermatitis or Atopy in FLG-Deficient Mice.

Allergens / immunology Animals Dermatitis, Atopic / etiology Female Filaggrin Proteins / deficiency Hypersensitivity / etiology Ichthyosis Vulgaris / etiology Mice Mice, Inbred BALB C Microbiota Skin / immunology Whole Genome Sequencing

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
11 2021
Historique:
received: 15 10 2020
revised: 19 01 2021
accepted: 03 02 2021
pubmed: 25 4 2021
medline: 15 12 2021
entrez: 24 4 2021
Statut: ppublish

Résumé

Loss of FLG causes ichthyosis vulgaris. Reduced FLG expression compromises epidermal barrier function and is associated with atopic dermatitis, allergy, and asthma. The flaky tail mouse harbors two mutations that affect the skin barrier, Flg

Identifiants

DOI: 10.1016/j.jid.2021.02.763 PMID: 33894197
pubmed: 33894197
pii: S0022-202X(21)01155-6
doi: 10.1016/j.jid.2021.02.763
pii:
doi:

Substances chimiques

Allergens 0
Filaggrin Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2611-2619.e2

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Lina Muhandes (L)

Institute for Immunology, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.

Maria Chapsa (M)

Department of Dermatology, University Hospital Carl Gustav Carus, School of Medicine, Dresden University of Technology, Dresden, Germany.

Martin Pippel (M)

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Rayk Behrendt (R)

Institute for Immunology, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.

Yan Ge (Y)

Institute for Immunology, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.

Andreas Dahl (A)

Deep Sequencing Group, Center for Regenerative Therapies Dresden, Dresden University of Technology, Dresden, Germany.

Buqing Yi (B)

Institute of Medical Microbiology and Hygiene, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.

Alexander Dalpke (A)

Institute of Medical Microbiology and Hygiene, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.

Sylke Winkler (S)

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Michael Hiller (M)

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Sebastien Boutin (S)

Departmant of Infectious Diseases, Medical Microbiology and Hygiene, University Hospital Heidelberg, Heidelberg, Germany.

Stefan Beissert (S)

Department of Dermatology, University Hospital Carl Gustav Carus, School of Medicine, Dresden University of Technology, Dresden, Germany.

Rolf Jessberger (R)

Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.

Padraic G Fallon (PG)

School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, Dublin, Ireland.

Axel Roers (A)

Institute for Immunology, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. Electronic address: axel.roers@tu-dresden.de.

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Antigènes › Allergènes › Low Threshold for Cutaneous Allergen...
questionsmedicales.fr › Eucaryotes › Animaux › Low Threshold for Cutaneous Allergen...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Eczéma atopique › Low Threshold for Cutaneous Allergen...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Protéines S100 › Protéines filaggrine › Low Threshold for Cutaneous Allergen...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Low Threshold for Cutaneous Allergen...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies génétiques de la peau › Ichtyose vulgaire › Low Threshold for Cutaneous Allergen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Low Threshold for Cutaneous Allergen...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › Low Threshold for Cutaneous Allergen...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Low Threshold for Cutaneous Allergen...
questionsmedicales.fr › Système tégumentaire › Peau › Low Threshold for Cutaneous Allergen...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Low Threshold for Cutaneous Allergen...